Extended Doxycycline Treatment Versus Aspiration of Hydrosalpingeal Fluid in the Management of Patients With Ultrasound Visible Hydrosalpinx Who Refused or Not Eligible to Undergo Salpingectomy Prior to IVF-ET

Usama M. Fouda, Hesham S. Elshaer, Sherin M. Sobh, Emad M Salah, Fatma F. Darweesh, Ahmed Wali, Tarek El Husseiny, Mohammad A. Taymour
In: Research Square · 2021 · doi:10.21203/rs.3.rs-138894/v1 · W4210513180
preprint OA: green CC0
📄 Open PDF View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06+body, 2026-06-10 ⓘ

This study compared extended doxycycline treatment versus ultrasound-guided aspiration of hydrosalpinx fluid, finding aspiration more effective for improving IVF-ET outcomes in patients who refused salpingectomy.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This retrospective study compared extended doxycycline therapy given during an IVF-ET cycle versus ultrasound-guided aspiration of hydrosalpinx fluid at ovum pick-up in patients with ultrasound-visible hydrosalpinx who refused or were not eligible for laparoscopic salpingectomy; 52 received doxycycline (100 mg every 12 h from one week before to one week after ovum pick-up) and 76 underwent aspiration, with similar baseline and stimulation characteristics. IVF-ET outcomes were higher with aspiration, including implantation (16.67% vs 8.33%), clinical pregnancy (32.89% vs 15.38%), ongoing pregnancy (30.26% vs 13.46%), and live birth (28.95% vs 13.46%), with all reported as statistically significant. A key limitation stated is that the findings require confirmation in subsequent randomized controlled studies. Relevance to endometriosis: the upstream text notes a prior retrospective study that included patients with unexplained infertility/endometriosis when comparing doxycycline across groups, though this paper’s main focus is hydrosalpinx management for IVF-ET rather than endometriosis.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

My notes (saved in your browser only)

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (2)

References (11)

Source provenance

europepmc
last seen: 2026-05-19T01:45:01.086888+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK