Hydrosalpinx treated with extended doxycycline does not compromise the success of in vitro fertilization
Observational
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⤵ 8 in-corpus citations
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This study investigated whether extended doxycycline treatment for hydrosalpinx negatively impacts in vitro fertilization success rates.
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Abstract
OBJECTIVE: To determine if extended treatment with doxycycline before and after an in vitro fertilization (IVF) procedure can minimize the detrimental effect of a hydrosalpinx.
DESIGN: Retrospective analysis.
SETTING: University IVF program.
PATIENT(S): Patients undergoing IVF, including 17 with a hydrosalpinx, 25 with adhesions or proximal tubal occlusion, and 22 with endometriosis or unexplained infertility.
INTERVENTION(S): Women with a documented hydrosalpinx were prescribed doxycycline 100 mg twice daily starting 1 week before expected retrieval and continued until 6 days after retrieval. No antibiotics were prescribed in the other groups.
MAIN OUTCOME MEASURE(S): Implantation rates and IVF outcomes.
RESULT(S): Implantation rates were 30% for the doxycycline-treated group of patients with a hydrosalpinx, 27% for the group with tubal occlusion/adhesion, and 24% for the group with endometriosis or unexplained infertility. Eight (47%) of 17 patients with a hydrosalpinx had a live birth, compared with 11 (44%) of 25 for the group with tubal occlusion/adhesion and 12 (55%) of 22 for the group with endometriosis/unexplained infertility. There were no differences between the groups in patient age, number of oocytes retrieved, fertilization rate, or number of blastomeres of the transferred embryos.
CONCLUSION(S): No detrimental effect of a hydrosalpinx was evident for patients treated with extended doxycycline. Tremendous cost savings can be realized if treatment with 2 weeks of an inexpensive antibiotic provides outcomes comparable to surgical correction of a hydrosalpinx before IVF.
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References (4)
- W2053854495 via openalex
- W2100475076 via openalex
- W2107052350 via openalex
- W2143020969 via openalex
Cited by (7)
- Extended Doxycycline Treatment Versus Aspiration of Hydrosalpingeal Fluid in the Management of Patients With Ultrasound Visible Hydrosalpinx Who Refused or Not Eligible to Undergo Salpingectomy Prior to IVF-ET 2021
- Hydrosalpinx: Tubal surgery or in vitro fertilisation? An everlasting dilemma nowadays; a narrative review 2017
- Proximal occlusion of hydrosalpinges by Essure(®) before assisted reproduction techniques: a French survey 2014
- Clinical factors affecting endometrial receptiveness in oocyte donation cycles 2008
- Surgical Preparation of the Patient for In Vitro Fertilization 2008
- [Clinical factors associated with the outcome of oocyte donation] 2007
- Expression of alpha 1 and beta 3 integrins subunits in the endometrium of patients with tubal phimosis or hydrosalpinx 2006
Source provenance
- europepmc
- last seen: 2026-10-15T06:08:49.021275+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-10-08T20:59:53.382863+00:00
License: CC0
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