Higher SOD1 Gene Expression in Cumulus Cells From Infertile Women With Moderate and Severe Endometriosis

Flávia Cappello Donabela, Juliana Meola, Cristiana Carolina Padovan, Cláudia Cristina Paro de Paz, Paula Andrea Navarro
Reproductive sciences (Thousand Oaks, Calif.) · 2015 · vol. 22(11) , pp. 1452–1460 · doi:10.1177/1933719115585146 · PMID:25947891 · W1540239684
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-06 ⓘ

Infertile women with moderate/severe endometriosis had higher SOD1 expression in cumulus cells compared to controls, with SOD1 potentially indicating clinical pregnancy after ICSI.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This case–control study measured expression of antioxidant genes SOD1, SOD2, and GPX4 by real-time PCR in cumulus cells from mature oocytes in infertile women undergoing controlled ovarian stimulation for ICSI, comparing minimal/mild endometriosis (n=26), moderate/severe endometriosis (n=14), and controls (n=41). The main finding was that only the moderate/severe endometriosis group showed higher SOD1 expression in cumulus cells relative to minimal/mild and controls, and increased SOD1 expression positively interacted with clinical pregnancy occurrence. A limitation is that gene expression was assessed in cumulus cells from participants at a single time point, with no direct functional mechanism shown. This paper is centrally about endometriosis — it links oxidative-stress–related antioxidant gene expression in cumulus cells (SOD1) to ICSI pregnancy outcomes specifically in moderate/severe endometriosis versus minimal/mild disease.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Cumulus Cells Endometriosis Infertility, Female Superoxide Dismutase Adult Case-Control Studies Cumulus Cells Endometriosis Endometriosis Female Humans Infertility, Female Infertility, Female Infertility, Female Infertility, Female Infertility, Female Prospective Studies Real-Time Polymerase Chain Reaction Reproductive Techniques, Assisted Severity of Illness Index

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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