Down-regulation of the CYP19A1 gene in cumulus cells of infertile women with endometriosis

Barcelos ID, Ionara Diniz E S Barcelos, Ionara Diniz Evangelista Santos Barcelos, Donabella FC, Flávia Capello Donabella, Ribas CP, Cristiana Padovan Ribas, Juliana Meola, Meola J, Ferriani RA, Rui Alberto Ferriani, de Paz CC, Cláudia Cristina Paro de Paz, Paula A Navarro, Paula Andrea Navarro
Reproductive biomedicine online · 2015 · vol. 30(5) , pp. 532–541 · doi:10.1016/j.rbmo.2015.01.012 · PMID:25773531 · W1987817990
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This study investigated the CYP19A1 gene in cumulus cells from infertile women with endometriosis, finding its expression was down-regulated.

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Abstract

Aromatase plays a fundamental role in the establishment of oocyte quality, which might be compromised in infertile women with endometriosis. The expression of the CYP19A1 gene (that encodes aromatase) was compared in cumulus cells and oestradiol concentrations in the follicular fluid of infertile women with and without endometriosis submitted to ovarian stimulation for intracytoplasmic sperm injection. Cumulus cells were isolated and the expression of the CYP19A1 was quantitated through real-time polymerase chain reaction. Oestradiol concentrations in follicular fluid were measured by chemiluminescence immunoassay. A lower expression of the CYP19A1 in the cumulus cells of infertile women with endometriosis was observed compared with controls (0.17 ± 0.13 and 0.56 ± 0.12, respectively), and no significant difference in the follicular fluid oestradiol concentrations was observed between groups. Our results show reduced expression of the CYP19A1 in cumulus cells of infertile women with endometriosis, which may play a role in the pathogenesis of endometriosis-related infertility.

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Condition tags

endometriosis

MeSH descriptors

Aromatase Cumulus Cells Down-Regulation Endometriosis Infertility, Female Aromatase Case-Control Studies Cumulus Cells Endometriosis Endometriosis Female Humans Infertility, Female Infertility, Female Ovulation Induction Pregnancy Pregnancy Rate Prospective Studies Sperm Injections, Intracytoplasmic

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