Aromatase P450 activity in the natural menstrual cycle and during controlled ovarian stimulation

Pavel Yakovlev
In: Journal of obstetrics and women's diseases · 2017 · vol. 66(5) , pp. 46–55 · doi:10.17816/jowd66546-55 · W2765899281
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This review synthesizes literature to show that ovarian aromatase is a key enzyme in female reproduction, with its activity influenced by multiple factors and potentially affecting ovarian response and oocyte quality in IVF.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

The paper is a narrative review that synthesizes literature from 1978–2016 to discuss aromatase P450 (CYP19A1) biology across the menstrual cycle and its implications for IVF, including how aromatase activity may influence follicular response and oocyte quality. It describes aromatase expression and regulation in ovarian cells (granulosa vs theca), regulation by gonadotropins and intracellular signaling (e.g., FSH/cAMP/CREB), and modulation by AMH and androgen substrates, alongside methods used to estimate aromatase activity (from invasive tissue approaches to serum-based indices using estradiol and AMH). The author’s stated limitation is that many direct measurement methods are costly or invasive, motivating discussion of less invasive surrogate approaches such as an estradiol-to-AMH “activity coefficient.” This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

The Aim of the study was to assess modern considerations about the role of aromatase P450 enzyme in female reproductive system and the effect of its activity on the protocols of in vitro fertilization (IVF). Materials: foreign and Russian literature data from 1978 to 2016. Methods:review and synthesis of publications has been performed. Conclusions: Ovarian aromatase is the key steroidogenesis enzyme of the female reproductive system. Its activity depends on many factors, both of intraovarian and extragonadal origin. The ovarian follicular response and oocyte quality in IVF may depend on aromatase activity.

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last seen: 2026-06-10T17:14:06.276822+00:00
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