Is there a benefit for surgery in endometrioma-associated infertility?
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⤵ 45 in-corpus citations
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Surgical removal of endometriomas does not improve fertility outcomes and can negatively impact ovarian reserve, function, and IVF success rates.
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Abstract
Purpose of review To summarize the literature related to the value of surgery in endometrioma-associated infertility and present the most recent evidence in support or against the surgical removal of endometriomas with special attention before commencing in-vitro fertilization (IVF) treatment. Recent findings Many studies support the evidence that surgical removal of endometriomas is deleterious to ovarian reserve and function. There is now convincing evidence that surgery for removal of endometriomas does not offer any additional benefits in terms of fertility outcomes. Other concerns after surgery are a higher risk of premature ovarian failure, earlier age at menopause, and higher cancellation rates in IVF cycles as well as the inherent risks of an invasive procedure. Summary Laparoscopic surgery for the removal of endometriomas is still a very common practice in the field of reproductive medicine. Although endometriomas per se may be detrimental to the ovarian reserve, the current evidence points toward an even lower ovarian reserve after surgery. Additionally, a reduced response of the ovaries to gonadotrophins has been described in different studies after surgical removal of endometriomas. The quality of the oocytes retrieved in IVF cycles is not improved after surgery. Patients going through an operative procedure might extend the time to pregnancy. Surgery should be envisaged only in specific circumstances such as pelvic pain or difficult access to growing follicles but not offered to every single patient with endometrioma-associated infertility.
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Cited by (45)
- Ethanol sclerotherapy twice and one laparoscopic surgery for stage IV pelvic endometriosis and bilateral ovarian endometrioma over two decades: a case report 2026
- Evaluation of endometrioma size effect on IVF outcomes in young infertile women candidates for IVF cycle 2025
- The optimal time for laparoscopic excision of ovarian endometrioma: a prospective randomized controlled trial 2023
- Analysis of cumulative live birth rate outcomes of three controlled ovarian hyperstimulation protocols in patients with diminished ovarian reserve following laparoscopic cystectomy of ovarial endometrioma: A retrospective cohort study 2023
- Analysis of cumulative live birth rate outcomes of three ovarian stimulation protocols in patients after laparoscopic cystectomy of ovarial endometrioma: a retrospective cohort study 2023
- The optimal time for laparoscopic excision of ovarian endometrioma: a prospective randomized controlled trial 2023
- "Dilemma in Management of Endometriotic Ovarian Cyst" 2022
- Effect of laparoscopic cystectomy on ovarian reserve in patients with ovarian cyst 2022
- Risk Factors for Anti Mullerian Hormone Decline after Laparoscopic Excision of Endometrioma: A Prospective Study 2022
- Does current ovarian endometrioma increase the time for DOR patients to reach live birth in IVF? 2022
- The ovarian reserve in infertile patients after bilateral endometrioid ovarian cysts removal with and without recurrence 2021
- Endometriosis-associated infertility: surgery or IVF? 2021
- Dienogest reduces endometrioma volume and endometriosis-related pain symptoms 2021
- Endometrioma surgery and possibilities of early disease control 2020
- ЕНДОМЕТРІОМИ ЯЄЧНИКІВ І ОВАРІАЛЬНИЙ РЕЗЕРВ 2020
- Oocyte vitrification for fertility preservation in women with endometriosis: an observational study 2020
- Could surgical management improve the IVF outcomes in infertile women with endometrioma?: a review 2019
- Ovarian cystectomy: Stitching or cauterizing – A comparison study of anti-mullerian hormone level pre- and postoperatively 2019
- Fertility Preservation in Women with Endometriosis: It is About Time We Talk About it! 2019
- Infertility Associated with Ovarian Endometriomas: Surgery or In-Vitro Fertilization? 2018
- Endometrioma and Ovarian Reserve: A Surgical Approach 2018
- Endométriome et prise en charge en FIV, RPC Endométriose CNGOF-HAS 2018
- Sclerotherapy in the management of ovarian endometrioma: systematic review and meta-analysis 2017
- Laparoscopic Surgery in the Treatment of Endometriosis 2017
- <i>In vitro</i>fertilization outcomes in women with surgery induced diminished ovarian reserve after endometrioma operation: Comparison with diminished ovarian reserve without ovarian surgery 2017
- Usefulness of hemostatic sealants for minimizing ovarian damage during laparoscopic cystectomy for endometriosis 2017
- Reproductive Outcomes of Segmented In Vitro Fertilization in Patients Diagnosed with Endometriomas 2017
- Deep infiltrating endometriosis affecting the urinary tract—surgical treatment and fertility outcomes in 2004–2013 2016
- A new approach to the management of ovarian endometrioma to prevent tissue damage and recurrence 2016
- Embryonic development after exposure of mouse oocyte to various amount of ovarian endometriotic fluid 2016
- Surgical diminished ovarian reserve after endometrioma cystectomy versus idiopathic DOR: comparison of in vitro fertilization outcome 2015
- Pregnancy Outcomes After Endometrioma Excision in Patients Undergoing <i>In Vitro</i> Fertilization and Embryo Transfer: A Historical Cohort Study 2015
- Sclerotherapy with Ethanol: An Effective and Safe Alternative to Potentially Complex Surgical Treatment of Recurrent Ovarian Endometrioma 2015
- IVF outcome in women with accidental contamination of follicular fluid with endometrioma content 2014
- Management of Endometriosis-Associated Infertility 2014
- Computer-assisted reproductive surgery: why it matters to reproductive endocrinology and infertility subspecialists 2014
- Expectativas de las pacientes afectadas de endometriosis moderada-severa ante la cirugía 2014
- The impact of endometrioma and laparoscopic cystectomy on ovarian reserve and the exploration of related factors assessed by serum anti-Mullerian hormone: a prospective cohort study 2014
- Is there a critical endometrioma size associated with reduced ovarian responsiveness in assisted reproduction techniques? 2014
- Surgical Therapy of Endometriosis: Challenges and Controversies 2013
- Pathophysiology proposed as the basis for modern management of the ovarian endometrioma 2013
- Endometrioma-Associated Infertility: Is Surgery Still the Best Way to Go? 2013
- The Ovarian Endometrioma: Clinical Setting and Ultrasound Findings 2013
- Do Low-Dose Oral Contraceptives have an Effect on Ovarian Endometrioma Diameter and Endometriosis Symptoms? 2013
- Surgical treatment of ovarian endometriomas: state of the art? 2012
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