Is there a critical endometrioma size associated with reduced ovarian responsiveness in assisted reproduction techniques?

Maria Elisabetta Coccia, Coccia ME, Francesca Rizzello, Rizzello F, Barone S, Stefano Barone, Sara Pinelli, Erika Rapalini, Rapalini E, Parri C, Cristiana Parri, Domenico Caracciolo, Caracciolo D, Savvas Papageorgiou, Papageorgiou S, Cima G, Gianpaolo Cima, Loredana Gandini, L. Gandini
Reproductive BioMedicine Online · 2014 · vol. 29(2) , pp. 259–266 · doi:10.1016/j.rbmo.2014.04.019 · PMID:24947067 · W1970396547
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This study investigated whether a specific endometrioma size exists that correlates with decreased ovarian response in patients undergoing assisted reproduction.

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Abstract

This study investigated the relationships between ovarian endometrioma size, ovarian responsiveness and the number of retrieved oocytes following ovarian stimulation. A prospective study was conducted in a public clinical assisted reproduction centre. A total of 64 infertile women with monolateral endometriomas undergoing IVF or intracytoplasmic sperm injection were included in the study. The total number of follicles, number of follicles ≥ 16 mm and number of oocytes retrieved of ovaries containing endometrioma and normal ovaries were compared. Multivariate linear regression was used to assess whether number of follicles and collected oocytes varied by endometrioma size, age, basal FSH concentration. Significantly lower numbers of follicles ≥ 16 mm (P = 0.024) and oocytes retrieved (P = 0.001) in the ovaries containing endometrioma were observed. In patients with endometriomas ≥ 30 mm, endometrioma size was the most influential contributor to the total number of follicles and oocytes retrieved. Ovarian endometriomas result in reduced response to ovarian stimulation, compared with the response of the contralateral normal ovary in the same individual. In case of endometriomas <30 mm, basal FSH concentration remains the most important prognostic factor for oocyte retrieval.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Endometrial Neoplasms Endometriosis Ovary Reproductive Techniques, Assisted Adult Endometrial Neoplasms Endometriosis Female Follicle Stimulating Hormone Follicle Stimulating Hormone Humans Ovary Prospective Studies

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