IVF outcome in women with accidental contamination of follicular fluid with endometrioma content

Laura Benaglia, Cardellicchio L, Lucia Cardellicchio, Cristina Guarneri, Guarneri C, Alessio Paffoni, Liliana Restelli, Restelli L, Edgardo Somigliana, Luigi Fedele
European journal of obstetrics, gynecology, and reproductive biology · 2014 · vol. 181 , pp. 130–134 · doi:10.1016/j.ejogrb.2014.07.036 · PMID:25150950 · W2102415201
article OA: closed CC0 ⤵ 16 in-corpus citations
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This study investigated IVF outcomes in women whose follicular fluid was accidentally contaminated with endometrioma contents during oocyte retrieval.

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Abstract

ObjectiveTo evaluate whether accidental contamination of follicular fluid with endometrioma content during oocytes retrieval affects IVF outcome.Study designWe set up a retrospective review of women undergoing IVF in our infertility unit during a four years period. Cases were 19 women with ovarian endometriomas who had an accidental aspiration of the endometrioma content during oocyte retrieval. Controls (n=38) were the two subsequent age-matched women with endometriomas who underwent an uncomplicated oocyte retrieval. The main outcome was to evaluate the clinical pregnancy rate in cases and in controls.ResultsAccidental aspiration of endometrioma content occurred in 19 out of 314 women (6.1%, 95%CI: 3.8-9.1%). The number of embryos and top quality embryos was significantly higher in exposed women (3.1±2.0 versus 1.7±1.2 and 1.9±1.5 versus 1.1±1.1, respectively) but the chances of pregnancy were lower. The adjusted RRs of clinical pregnancy and live birth were 0.63 (95%CI: 0.49-0.87, p=0.005) and 0.60 (95%CI: 0.51-086, p=0.003), respectively.ConclusionAccidental contamination of the follicular fluid with endometrioma content is an uncommon but possible event. This situation may affect IVF outcome but does not justify systematic surgical removal before the cycle.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Endometriosis Fertilization in Vitro Follicular Fluid Live Birth Oocyte Retrieval Pregnancy Rate Adult Endometriosis Female Humans Infertility, Female Infertility, Female Infertility, Female Oocyte Retrieval Pregnancy Retrospective Studies

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