High concentrations of the vascular endothelial growth factor and interleukin-8 in ovarian endometriomata

Fasciani A, Alessandro Fasciani, A Fasciani, G D'Ambrogio, D'Ambrogio G, G Bocci, Guido Bocci, M Monti, Monti M, A. R. Genazzani, Genazzani AR, P. G. Artini, Artini PG
Molecular human reproduction · 2000 · vol. 6(1) , pp. 50–54 · doi:10.1093/molehr/6.1.50 · PMID:10611260 · W2162415686
Observational OA: bronze CC0 ⤵ 86 in-corpus citations
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Ovarian endometriomata cyst fluids contained significantly higher concentrations of vascular endothelial growth factor and interleukin-8 than control follicular cysts, suggesting angiogenesis is involved in their development and maintenance.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Patients with endometriosis are characterized by the ability of the endometrium to implant and by the peritoneal response to the tissue; angiogenic factors may play a significant role in the aetiology of endometriosis supporting the implantation of ectopic endometrial cells. Vascular endothelial growth factor (VEGF) is a mitogen, morphogen and chemoactractant for endothelial cells and, in vivo, it is a powerful mediator for vessel permeability. Interleukin-8 (IL-8) is a chemoatractant for neutrophils and is a potent angiogenic factor. Women (n = 20) with ovarian endometriomata and 10 women with follicular cysts were enrolled in this study to investigate the role of VEGF and IL-8 in the development and maintenance of ovarian endometriomata. Cystic fluids were collected by laparoscopy, immediately centrifuged and stored until the enzyme-linked immunosorbent assays were performed. The VEGF and IL-8 concentrations were found to be significantly higher in the fluids of the ovarian endometriomata than in those of the follicular cysts of controls (P < 0.001 and P < 0.001 respectively); in addition, a significant inverse correlation between the VEGF cystic fluid concentrations and the diameter of the endometriotic adnexal masses was found (r = -0.56, P = 0.01). The evidence that the high concentrations of VEGF and IL-8 are present in the ovarian endometriomata indicates that angiogenesis could be a specific event both for the progression and maintenance of such cysts.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Endothelial Growth Factors Interleukin-8 Lymphokines Adult Adult CA-125 Antigen CA-125 Antigen CA-125 Antigen Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endothelial Growth Factors Endothelial Growth Factors Female Female Follicular Cyst

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (29)

Cited by (50)

Source provenance

europepmc
last seen: 2026-10-16T06:09:50.462052+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T20:59:14.592962+00:00
License: CC0 · commercial use OK