Intrafollicular iron and ferritin in women with ovarian endometriomas

Laura Benaglia, Alessio Paffoni, Alice Mangiarini, Mangiarini A, Restelli L, Liliana Restelli, Nora Bettinardi, Bettinardi N, Edgardo Somigliana, Paolo Vercellini, Luigi Fedele
Acta obstetricia et gynecologica Scandinavica · 2015 · vol. 94(6) , pp. 646–653 · doi:10.1111/aogs.12647 · PMID:25846033 · W1997739530
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This study found higher ferritin but not iron concentrations in follicular fluid from ovaries with endometriomas, suggesting ferritin sequesters iron to limit detrimental effects on ovarian function.

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Abstract

OBJECTIVE: To evaluate whether iron contained in ovarian endometriomas can diffuse through the cyst wall and negatively affect ovarian function. DESIGN: Prospective case series. SETTING: Infertility unit in an academic setting. POPULATION: Thirty-nine infertile women with unilateral endometriomas who underwent in vitro fertilization. METHODS: Iron and ferritin assessments in pools of follicular fluids obtained from affected and contralateral intact gonads. MAIN OUTCOME MEASURES: Iron and ferritin concentrations. RESULTS: Follicular fluid iron content did not differ between the two gonads. The median [interquartile range (IQR)] follicular concentrations in the affected and unaffected ovaries were 59 (IQR 44-74) and 59 (IQR 47-73) μg/dL, respectively (p = 0.77). Conversely, ferritin concentration was significantly higher in affected gonads. The median (IQR) concentrations of ferritin in the affected and unaffected ovaries were 57 (IQR 31-146) and 33 (IQR 23-67) μg/mL, respectively (p = 0.026). When considering together the 78 studied ovaries, no significant correlations emerged between follicular iron and ferritin and variables reflecting ovarian responsiveness and oocyte developmental competence. CONCLUSIONS: Iron may diffuse from ovarian endometriomas into the adjacent ovarian tissue. However, this phenomenon does not appear to markedly affect ovarian function. Some effective biological mechanisms such as ferritin storage may effectively sequester free iron, so limiting its detrimental effects.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Ferritins Infertility, Female Iron Ovarian Diseases Ovarian Follicle Adult Endometriosis Endometriosis Female Ferritins Humans Infertility, Female Infertility, Female Infertility, Female Iron Italy Ovarian Diseases Ovarian Diseases Ovarian Follicle

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License: CC0 · commercial use OK