Effects on in vitro fertilization–embryo transfer outcomes of vascular endothelial growth factor receptor‐1, ‐2 and ‐3 in eutopic endometrial tissue of women with endometriosis

Chung‐Hoon Kim, Chung-Hoon Kim, Jun-Woo Ahn, Jun‐Woo Ahn, Sung‐Hoon Kim, Sung-Hoon Kim, Sung Hoon Kim, Hee‐Dong Chae, Hee-Dong Chae, Byung-Moon Kang, Byung‐Moon Kang
Journal of Obstetrics and Gynaecology Research · 2011 · vol. 37(11) , pp. 1631–1637 · doi:10.1111/j.1447-0756.2011.01588.x · PMID:21733043 · W1500011402
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study found that women with endometriosis had higher expression of VEGFR-1, -2, and -3 mRNA in their eutopic endometrium, which was associated with lower implantation rates and poorer pregnancy outcomes in IVF-ET.

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Abstract

AIM: This study was performed to assess the expression levels of vascular endothelial growth factor receptor (VEGFR)-1, -2 and -3 mRNA in eutopic endometrial tissue and their effects on in vitro fertilization-embryo transfer (IVF-ET) outcomes in women with endometriosis. MATERIALS AND METHODS: Twenty women with endometriosis III or IV (study group) and 20 with tubal infertility only (control group) were evaluated. Controlled ovarian stimulation in all patients consisted of the long protocol using gonadotrophin-releasing hormone agonist. Prior to the administration of 0.1 mg triptorelin daily in the mid-luteal phase of the preceding menstrual cycle, a biopsy specimen was taken from the endometrial cavity, and the expression levels of VEGFR-1, -2 and -3 mRNA were analyzed with real-time reverse transcription-polymerase chain reaction. RESULTS: There were no significant differences in the numbers of retrieved oocytes and mature oocytes, fertilization rate and clinical pregnancy rate between the study and control groups. However, the implantation rate was significantly lower in the study group (P < 0.05). The relative amounts of VEGFR-1, -2 and -3 mRNA were significantly higher in the study group than in the control group (P < 0.001 each). The relative amounts of VEGFR-1 and -3 mRNA were significantly higher in the non-pregnant than in the pregnant subgroup of the study group (P < 0.01, P < 0.05, respectively). CONCLUSIONS: Increased expression of VEGFR in the endometrium, especially VEGFR-1 and -3, may be related to the development of endometriosis and may reduce the receptivity of the endometrium.

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Condition tags

endometriosisinfertility

MeSH descriptors

Embryo Transfer Endometriosis Endometrium Fertilization in Vitro Infertility, Female Receptors, Vascular Endothelial Growth Factor Adult Embryo Implantation Embryo Implantation Endometriosis Endometrium Female Humans Infertility, Female Infertility, Female Pregnancy Pregnancy Rate Receptors, Vascular Endothelial Growth Factor Treatment Outcome Vascular Endothelial Growth Factor Receptor-1

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