Effects of peritoneal macrophages from patients with endometriosis on the proliferation of endometrial carcinoma cell line ECC-1

Zhang RJ, Renjie Zhang, R J Zhang, R A Wild, Robert A. Wild, Wild RA, Medders D, Diane Medders, D Medders, Subba Rao Gunupudi, Gunupudi SR, S R Gunupudi
American journal of obstetrics and gynecology · 1991 · vol. 165(6) , pp. 1842–1846 · doi:10.1016/0002-9378(91)90043-q · PMID:1750484 · W2060109637
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Peritoneal macrophages from women with endometriosis inhibited the proliferation of the endometrial carcinoma cell line ECC-1 in vitro.

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Abstract

Endometriosis has been shown to be associated with increased number and activity of peritoneal macrophages. The peritoneal macrophage-conditioned media from 33 women with or without endometriosis were studied for their effects on an endometrial carcinoma cell line, ECC-1. The media from six of six stage III/IV cases demonstrated a mitogenic effect, which was blocked by an antibody to epidermal growth factor receptor. However, the conditioned media from seven of nine stage I/II cases and 14 of 18 normal women did not show a mitogenic effect. The difference between stage III/IV and the other two groups was significant (p less than 0.01). The incorporation of tritium-thymidine was three times higher with the media from stage III/IV cases, as compared with that of controls. When purified cytokines were tested in the tritium-thymidine uptake assay, only epidermal growth factor-transforming growth factor-alpha was mitogenic on ECC-1, whereas tumor necrosis factor, interleukin-1, and platelet-derived growth factor had no effect. Thus peritoneal macrophages in patients with endometriosis may play an important role in the progression of endometriosis, and the noted effects could be mediated by epidermal growth factor or a related growth factor.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Macrophages Uterine Neoplasms Cell Division Culture Media Endometriosis Female Humans Interleukin-1 Interleukin-1 Macrophages Neoplasm Staging Peritoneal Cavity Peritoneal Cavity Platelet-Derived Growth Factor Platelet-Derived Growth Factor Transforming Growth Factor alpha Transforming Growth Factor alpha Tumor Cells, Cultured Tumor Cells, Cultured

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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