Serum level of IL-10 is increased in patients with endometriosis, and IL-10 promotes the growth of lesions in a murine model

Jau-Ling Suen, Jau‐Ling Suen, Chang Y, Yu Chang, Pu-Rong Chiu, Chiu PR, Tsung-Hua Hsieh, Tsung‐Hua Hsieh, Hsieh TH, Edward Hsi, Hsi E, Yu-Chieh Chen, Chen YC, Yu‐Chieh Chen, Yufang Chen, Chen YF, Yu-Fang Chen, Tsai EM, Eing-Mei Tsai, Eing‐Mei Tsai
The American Journal of Pathology · 2013 · vol. 184(2) , pp. 464–471 · doi:10.1016/j.ajpath.2013.10.023 · PMID:24326257 · W2090330334
Lab / animal OA: bronze CC0 ⤵ 73 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

Serum IL-10 levels are elevated in endometriosis patients, and this cytokine promotes lesion growth in a murine model.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Immune dysregulation may be involved in the development of endometriosis. The anti-inflammatory cytokine IL-10 plays an important role in eliminating unwanted cells and cellular debris in a silent way. We investigated the modulatory role of IL-10 in the development of endometriosis. We observed that the serum level of IL-10 in patients with endometriosis was significantly higher than that in healthy subjects or in control subjects with other gynecological disease. Monocyte-derived dendritic cells acquired from male donors and subsequently conditioned with serum from women with endometriosis exhibited a tolerogenic phenotype, including increased IL-10 production, lower IL-12 secretion, and down-regulation of CD86 and HLA-DR molecules. Depletion of IL-10 activity in a C57BL/6 mouse model of surgically induced endometriosis significantly decreased the size of endometrial lesions. In contrast, IL-10 administration promoted the growth of endometrial lesions in this model. In addition, infiltrated plasmacytoid dendritic cells were the primary IL-10-secreting immune cells in endometrial lesions. Our findings suggest that IL-10 may suppress immunity against endometrial implants, contributing to development of endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Interleukin-10 Adult Adult Animals Animals Antibodies, Blocking Antibodies, Blocking Antibodies, Blocking Case-Control Studies Case-Control Studies Cells, Cultured Cells, Cultured Culture Media, Conditioned Culture Media, Conditioned Culture Media, Conditioned Demography Demography Dendritic Cells

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (44)

Cited by (50)

Source provenance

europepmc
last seen: 2026-10-13T06:10:10.580696+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:12:56.342978+00:00
License: CC0 · commercial use OK