Glycyrrhizin inhibits LPS-induced inflammatory mediator production in endometrial epithelial cells

Wang XR, Xue-Rong Wang, Xuerong Wang, Hao HG, Hong-guang Hao, Lan H. Chu, Lan Chu, Chu L
Microbial pathogenesis · 2017 · vol. 109 , pp. 110–113 · doi:10.1016/j.micpath.2017.05.032 · PMID:28552807 · W2617869492
Lab / animal OA: closed CC0 ⤵ 7 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

Glycyrrhizin was found to inhibit the production of inflammatory mediators in endometrial epithelial cells stimulated by lipopolysaccharide.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Endometriosis is a continuous inflammation of uterine endometrium that usually affects women of reproductive age. Glycyrrhizin, a triterpene isolated from the roots and rhizomes of licorice (Glycyrrhiza glabra), has been known to have anti-inflammatory effect. The purpose of this study was to investigate the anti-inflammatory effect of glycyrrhizin on LPS-stimulated mouse endometrial epithelial cells (MEEC). The levels of TNF-α, IL-1β, and PGE2 were measured by ELISA. The expression of COX-2, iNOS, TLR4, and NF-ĸB were detected by western blot analysis. The results showed that glycyrrhizin significantly suppressed LPS-induced TNF-α, IL-1β, NO, and PGE2 production. Also, LPS-induced iNOS and COX-2 expression were attenuated by glycyrrhizin. Furthermore, glycyrrhizin significantly attenuated TLR4 expression and NF-κB activation induced by LPS in MEEC. In conclusion, the present study demonstrated that glycyrrhizin inhibited LPS-induced inflammatory response by inhibiting TLR4 signaling pathway in MEEC. Glycyrrhizin may be used as a potential agent for the treatment of endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Anti-Inflammatory Agents Epithelial Cells Glycyrrhizic Acid Inflammation Mediators Animals Animals Anti-Inflammatory Agents Anti-Inflammatory Agents Cell Culture Techniques Cell Culture Techniques Cell Line Cell Line Cell Survival Cell Survival Cell Survival Cyclooxygenase 2 Cyclooxygenase 2 Cyclooxygenase 2 Cytokines Cytokines

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (28)

Cited by (7)

Source provenance

europepmc
last seen: 2026-10-09T06:09:53.026058+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:20:02.015990+00:00
License: CC0 · commercial use OK