{"paper_id":"a22523e7-2dce-4768-9967-1b7d9d410a8d","body_text":"Abstract\nIntroduction\nEndometriosis is defined as the presence of endometrial tissue outside the uterine cavity.\nMaterials and Methods\nThe etiology of this multifactorial disease is still unresolved and an increasing number of studies suggest that genetic, hormonal, environmental, immunological and oxidative factors may all play an important role in the pathogenesis of this disorder.\nConclusions\nIn this literature review, inflammatory activity, oxidative stress as well as genetic abnormalities and mutations have been studied in an effort to identify factors predisposing to endometriosis.\nSimilar content being viewed by others\nReferences\nKoninckx PR (1999) The physiopathology of endometriosis: pollution and dioxin. Gynecol Obstet Invest 47(Suppl 1):47–49 (discussion 50)\nDonnez J et al (2002) The efficacy of medical and surgical treatment of endometriosis-associated infertility and pelvic pain. 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Ginekol Pol 82(3):191–194\nMier-Cabrera J et al (2008) Effect of vitamins C and E supplementation on peripheral oxidative stress markers and pregnancy rate in women with endometriosis. Int J Gynaecol Obstet 100(3):252–256\nMier-Cabrera J et al (2009) Women with endometriosis improved their peripheral antioxidant markers after the application of a high antioxidant diet. Reprod Biol Endocrinol 7:54\nConflict of interest\nNone.\nAuthor information\nAuthors and Affiliations\nCorresponding author\nRights and permissions\nAbout this article\nCite this article\nAugoulea, A., Alexandrou, A., Creatsa, M. et al. Pathogenesis of endometriosis: the role of genetics, inflammation and oxidative stress. Arch Gynecol Obstet 286, 99–103 (2012). https://doi.org/10.1007/s00404-012-2357-8\nReceived:\nAccepted:\nPublished:\nIssue date:\nDOI: https://doi.org/10.1007/s00404-012-2357-8","source_license":"CC0","license_restricted":false}