Autoreactivity in women with endometriosis

Pamela V. Taylor, Taylor PV, P V Taylor, M D Maloney, Michael D. Maloney, Maloney MD, Campbell JM, James M. Campbell, J M Campbell, Skerrow SM, S M Skerrow, SYLVIA M. SKERROW, M M Nip, Nip MM, MARIA M. C. NIP, R Parmar, Parmar R, Rekha Parmar, G Tate, Tate G, GEOFFREY TATE
British journal of obstetrics and gynaecology · 1991 · vol. 98(7) , pp. 680–684 · doi:10.1111/j.1471-0528.1991.tb13455.x · PMID:1883792 · W1999061705
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Women with endometriosis exhibited a significantly higher prevalence of various autoantibodies, including antinuclear and smooth muscle antibodies, and elevated IgG and IgM levels compared to control subjects.

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Abstract

Serum samples from 71 patients with laparoscopically staged endometriosis and from 109 age-matched non-pregnant control women were tested for antibodies to nuclear, phospholipid, smooth muscle and sperm antigens. Immunoglobulin G, M and A and complement components C3 and C4 were measured. Prevalence of the following autoantibodies was statistically significantly greater in women with endometriosis than in the control group: antinuclear antibodies, antibodies to ribonucleoproteins, smooth muscle antibodies, lupus anticoagulant and anticardiolipin antibody. Forty-one women with endometriosis (58%) had some type of autoantibody compared with 13 controls (12%). More women in the endometriosis group had IgG and IgM levels above the normal range. This was statistically significant for IgG in women with grade 3 and for IgM in those with grade 4 endometriosis, IgG levels were significantly higher in antibody-positive women with endometriosis than in the control group. Immunoglobulin and complement component levels tended to have a positive correlation with stage of disease.

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Condition tags

endometriosis

MeSH descriptors

Antibodies Endometriosis Adolescent Adult Antibodies Autoantibodies Autoantibodies Cardiolipins Cardiolipins Complement C3 Complement C3 Complement C4 Complement C4 Endometriosis Female Fluorescent Antibody Technique Humans Immunoglobulin A Immunoglobulin A Immunoglobulin G

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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