Prévalence et caractéristiques de l’auto-immunité sérique chez les patientes suivies pour infertilité au CHU de Grenoble

C. Wackenheim, Wackenheim C, Chloé Wackenheim, Pascale Hoffman, Hoffman P, Dumestre-Pérard C, Chantal Dumestre-Pérard, Chantal Dumestre‐Pérard, Laurence Bouillet, Bouillet L, Nadia Alfaidy, Alban Deroux
Presse medicale (Paris, France : 1983) · 2019 · vol. 48(11) , pp. e307–e315 · doi:10.1016/j.lpm.2019.10.002 · PMID:31727487 · W2988262675
article OA: bronze CC0
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-13 ⓘ

This study investigated the prevalence and characteristics of serum autoimmunity in infertile women treated at the Grenoble University Hospital Center.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

IntroductionFertility disorders in autoimmune diseases are well described. However, little is known about the presence of a humoral serum autoimmunity in case of infertility (antinuclear antibodies, ACAN or antiphospholipid, APL) without criteria of autoimmune disease.MethodsWe studied the prevalence, associated factors, and efficacy of immunomodulatory therapy in patients with unexplained infertility. Two groups were created retrospectively among patients followed in medically assisted procreation (PMA) for infertility: a group with serum autoimmunity (AI+) (ACAN, APL or anti-thyroperoxidase antibodies) and a group without serum autoimmunity (HAVE-). Clinical, biological, and therapeutic data were collected.ResultsThe prevalence of autoimmunity was 33% among consultant patients. One hundred patients were seen in internal medicine consultation, 70 were included in the AI+ group and 30 in the AI- group. In the AI+ group, 76% had ACANs, 29% had anti-TPOs and 23% had APLs. There was a significant correlation between ACAN level and the presence of endometriosis (P=0.048). Immunomodulatory therapy was introduced for 68 of the 70 women in the AI+ group; pregnancy occurred in 28 patients (40%) during the treatment period, compared with 7 in the "AI-" group (23%), with a tendency to significance (P=0.09). In conclusion, there is an increased prevalence of serum autoimmunity in patients with fertility disorders, possibly with the efficacy of an immunomodulatory treatment to confront prospective therapeutic studies.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Autoantibodies Autoimmunity Infertility, Female Antibodies, Antinuclear Antibodies, Antinuclear Antibodies, Antiphospholipid Antibodies, Antiphospholipid Autoantibodies Autoantigens Autoantigens Embryo Implantation Endometriosis Endometriosis Female France Humans Immunomodulation Infertility, Female Infertility, Female Infertility, Female

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (4)

References (19)

Source provenance

europepmc
last seen: 2026-07-31T06:09:14.520117+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:22:29.487098+00:00
License: CC0 · commercial use OK