Prednisolone plus low-dose aspirin improves the implantation rate in women with autoimmune conditions who are undergoing in vitro fertilization

Isao Hasegawa, Yasuaki Yamanoto, Mina Suzuki, Haruo Murakawa, Takumi Kurabayashi, Koichi Takakuwa, Kenichi Tanaka
In: Fertility and Sterility · 1998 · vol. 70(6) , pp. 1044–1048 · doi:10.1016/s0015-0282(98)00343-4 · PMID:9848293 · W2086834246
article OA: bronze CC0 ⤵ 3 in-corpus citations
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Prednisolone combined with low-dose aspirin demonstrated an improved implantation rate in women with autoimmune conditions undergoing in vitro fertilization.

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Abstract

ObjectiveTo evaluate the effect of prednisolone plus low-dose aspirin (PSL/LDA) in women with autoimmune conditions who were enrolled in an IVF-ET program.DesignA retrospective clinical study.SettingIn vitro fertilization unit, Niigata University Hospital, Niigata, Japan.Patient(s)Three hundred seven women who underwent IVF-ET between January 1996 and December 1997.Intervention(s)Prednisolone (10 mg/d) and aspirin (81 mg/d) were administered to the women with autoantibodies who chose to participate.Main outcome measure(s)Pregnancy and implantation rates with IVF-ET.Result(s)Women undergoing IVF who had positive antinuclear antibodies, with or without antiphospholipid antibodies, had significantly lower pregnancy and implantation rates than did women without autoantibodies (14.8% versus 21.7% and 6.8% versus 10.4%, respectively). The administration of PSL/LDA to women with antinuclear antibodies significantly improved the outcome of IVF-ET (40.6% pregnancy rate and 20.3% implantation rate).Conclusion(s)A high proportion of women who are undergoing IVF-ET have autoantibodies, which are associated with poor IVF outcomes. The administration of PSL/LDA to these women may improve their implantation rate.

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