Autoreactivity in women with endometriosis

Pamela V. Taylor, Taylor PV, P V Taylor, M D Maloney, Michael D. Maloney, Maloney MD, Campbell JM, James M. Campbell, J M Campbell, Skerrow SM, S M Skerrow, SYLVIA M. SKERROW, M M Nip, Nip MM, MARIA M. C. NIP, R Parmar, Parmar R, Rekha Parmar, G Tate, Tate G, GEOFFREY TATE
British journal of obstetrics and gynaecology · 1991 · vol. 98(7) , pp. 680–684 · doi:10.1111/j.1471-0528.1991.tb13455.x · PMID:1883792 · W1999061705
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Women with endometriosis exhibited a significantly higher prevalence of various autoantibodies, including antinuclear and smooth muscle antibodies, and elevated IgG and IgM levels compared to control subjects.

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Abstract

Serum samples from 71 patients with laparoscopically staged endometriosis and from 109 age-matched non-pregnant control women were tested for antibodies to nuclear, phospholipid, smooth muscle and sperm antigens. Immunoglobulin G, M and A and complement components C3 and C4 were measured. Prevalence of the following autoantibodies was statistically significantly greater in women with endometriosis than in the control group: antinuclear antibodies, antibodies to ribonucleoproteins, smooth muscle antibodies, lupus anticoagulant and anticardiolipin antibody. Forty-one women with endometriosis (58%) had some type of autoantibody compared with 13 controls (12%). More women in the endometriosis group had IgG and IgM levels above the normal range. This was statistically significant for IgG in women with grade 3 and for IgM in those with grade 4 endometriosis, IgG levels were significantly higher in antibody-positive women with endometriosis than in the control group. Immunoglobulin and complement component levels tended to have a positive correlation with stage of disease.

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Condition tags

endometriosis

MeSH descriptors

Antibodies Endometriosis Adolescent Adolescent Adult Adult Antibodies Antibodies Autoantibodies Autoantibodies Autoantibodies Cardiolipins Cardiolipins Cardiolipins Complement C3 Complement C3 Complement C3 Complement C4 Complement C4 Complement C4

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (26)

Cited by (49)

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