Endometriose – vi har lett på feil sted

Mikael Røijen
In: Tidsskrift for Den norske legeforening · 2026 · vol. 146(9) · doi:10.4045/tidsskr.26.0332 · PMID:42622395 · W7203833672
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⚙ AI-generated summary by qwen3.7-flash, 2026-09-16 ⓘ

This editorial argues that research into endometriosis has focused on incorrect areas, suggesting a need to redirect scientific investigation toward more relevant targets for understanding the condition.

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⚙ AI-generated deep summary by qwen3.7-flash, 2026-09-16 · read from full text ⓘ

The provided text consists of a reference list rather than a single cohesive research article, compiling numerous studies on the genetics, comorbidities, and diagnostic challenges of endometriosis. Key papers reviewed include investigations into genetic links with ovarian cancer, the role of microbiota in infertility, and the impact of central sensitization on pain outcomes after surgery. The collection highlights the systemic nature of the disease, covering topics from immune mechanisms to long-term life-course impacts. This paper is centrally about endometriosis — specifically serving as a bibliography for recent major reviews and primary research articles regarding its pathophysiology, diagnosis, and comorbidities.

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Abstract

Endometriose -vi har lett på feil sted KRONIKK
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As-Sanie S, Mackenzie SC, Morrison L et al. Endometriosis: A Review. JAMA 2025; 334: 64–78. [PubMed][CrossRef] Taylor HS, Kotlyar AM, Flores VA. Endometriosis is a chronic systemic disease: clinical challenges and novel innovations. Lancet 2021; 397: 839–52. [PubMed][CrossRef] Rahmioglu N, Mortlock S, Ghiasi M et al. The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions. Nat Genet 2023; 55: 423–36. [PubMed][CrossRef] Petraglia F, Vannuccini S, Donati C et al. Endometriosis and comorbidities: molecular mechanisms and clinical implications. Trends Mol Med 2026; 32: 484–98. [PubMed][CrossRef] Reis JL, Rosa NN, Ângelo-Dias M et al. Natural Killer Cell Receptors and Endometriosis: A Systematic Review. Int J Mol Sci 2022; 24: 331. [PubMed][CrossRef] Lv H, Liu B, Dai Y et al. TET3-overexpressing macrophages promote endometriosis. J Clin Invest 2024; 134: e181839. [PubMed][CrossRef] Lee GJ, Hode V, Georgieva T et al. Prolactin-induced sensitization of trigeminal nociceptors promotes migraine co-morbidity in endometriosis. Cephalalgia 2025; 45: 3331024241313378. [PubMed][CrossRef] Salliss ME, Farland LV, Mahnert ND et al. The role of gut and genital microbiota and the estrobolome in endometriosis, infertility and chronic pelvic pain. Hum Reprod Update 2021; 28: 92–131. [PubMed][CrossRef] Peyneau M, Kavian N, Chouzenoux S et al. Role of thyroid dysimmunity and thyroid hormones in endometriosis. Proc Natl Acad Sci U S A 2019; 116: 11894–9. [PubMed][CrossRef] Orr NL, Huang AJ, Liu YD et al. Association of Central Sensitization Inventory Scores With Pain Outcomes After Endometriosis Surgery. JAMA Netw Open 2023; 6: e230780. [PubMed][CrossRef] Breton Z, Gouesbet S, Indersie E et al. Endometriosis Diagnostic Delay and Its Correlates: Results from the ComPaRe-Endometriosis Cohort. J Womens Health (Larchmt) 2026; 35: 172–88. [PubMed] Missmer SA, Tu FF, Agarwal SK et al. Impact of Endometriosis on Life-Course Potential: A Narrative Review. Int J Gen Med 2021; 14: 9–25. [PubMed][CrossRef] Mortlock S, Corona RI, Kho PF et al. A multi-level investigation of the genetic relationship between endometriosis and ovarian cancer histotypes. Cell Rep Med 2022; 3: 100542. [PubMed][CrossRef] Lu D, Song H, Shi G. Anti-TNF-α treatment for pelvic pain associated with endometriosis. Cochrane Database Syst Rev 2013; CD008088. [PubMed][CrossRef] Bendifallah S, Roman H, Suisse S et al. Validation of a Saliva Micro-RNA Signature for Endometriosis. NEJM Evid 2025; 4: a2400195. [PubMed][CrossRef] ()

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (13)

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