Relationship of Endometriosis with Cortisol and Thyroid Function in Young Working Females

Iram Qamar, Saima Mukhtar, Mah E Jabeen, Sara Naeem, Javeria latif, Shaista Hussain
In: Annals of Punjab Medical College · 2024 · vol. 18(1) , pp. 11–15 · doi:10.29054/apmc/2024.1581 · W4396647045
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This study found that young working females with endometriosis had lower TSH, higher estrogen and cortisol, and altered T3/T4 levels, suggesting a link between endometriosis and thyroid dysfunction.

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This cross-sectional study evaluated serum T3, T4, TSH, cortisol, and estrogen in 55 young working females with endometriosis and 15 controls using ELISA assays. Compared with controls, endometriosis patients had lower TSH, higher estrogen, and higher cortisol, and the paper reports an imbalance in thyroid hormones with increased T4 but decreased T3 in endometriotic cells. The authors attribute possible thyroid dysfunction to hormone imbalance and note a limitation in design and generalizability given the small control group and single cross-sectional snapshot. Relevance to endometriosis: the study specifically examines how endometriosis relates to thyroid function markers (TSH, T3, T4) and cortisol, concluding that endometriosis is associated with thyroid malfunction and hormone imbalance.

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Abstract

Objective: The study was focused to evaluate the role of endometriosis in development of hypothyroidism in working females subjected to chronic stress. Study Design: cross sectional study. Settings: This research was conducted at department of Gynecology & Obstetrics, The University of Lahore Teaching Hospital, Lahore. Duration: The research was completed in from February 2023 to February 2024. Methods: Serum samples of fifty-five endometriosis patients and fifteen controls were analyzed for T3, T4, TSH, cortisol and estrogen levels by using ELISA kits. Results: The levels of TSH in patient’s serum is (1.02±0.168mIU/L) as related to control (3.08±1.090 mIU/L) were lower in females with endometriosis. Serum estrogen levels in endometriosis patients (67.07±5.54 pg/ml) were higher than normal controls (21.07±3.66pg/ml). Elevated levels of serum cortisol (27.25±3.27) than normal values (11.19±4.18) in endometriosis patients were observed. Thyroid problems may result from this imbalance. Furthermore, there is a change in the quantity of thyroid hormones (T3 and T4) in endometriotic cells. Production of T4 rose whereas that of T3 fell. Thus, our research shows that endometriosis increases the risk of thyroid malfunction and hormone imbalance in women. Conclusion: We came to the conclusion that thyroid hormone contributes to endometriosis because endometrial cells are sensitive to changes in TSH. The thyroid gland and its related hormone concentrations described a varied picture between healthy subjects and patients of endometriosis. Moreover, thyroid hormones and estrogen are found to play their significant roles in the disease.
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Relationship of Endometriosis with Cortisol and Thyroid Function in Young Working Females Endometriosis in Young Working Females with Hormone Dysfunction DOI: https://doi.org/10.29054/apmc/2024.1581Keywords: Thyroid hormones, Endometriosis, Hypothyroidism, EstrogenAbstract Objective: The study was focused to evaluate the role of endometriosis in development of hypothyroidism in working females subjected to chronic stress. Study Design: cross sectional study. Settings: This research was conducted at department of Gynecology & Obstetrics, The University of Lahore Teaching Hospital, Lahore. Duration: The research was completed in from February 2023 to February 2024. Methods: Serum samples of fifty-five endometriosis patients and fifteen controls were analyzed for T3, T4, TSH, cortisol and estrogen levels by using ELISA kits. Results: The levels of TSH in patient’s serum is (1.02±0.168mIU/L) as related to control (3.08±1.090 mIU/L) were lower in females with endometriosis. Serum estrogen levels in endometriosis patients (67.07±5.54 pg/ml) were higher than normal controls (21.07±3.66pg/ml). Elevated levels of serum cortisol (27.25±3.27) than normal values (11.19±4.18) in endometriosis patients were observed. Thyroid problems may result from this imbalance. Furthermore, there is a change in the quantity of thyroid hormones (T3 and T4) in endometriotic cells. Production of T4 rose whereas that of T3 fell. Thus, our research shows that endometriosis increases the risk of thyroid malfunction and hormone imbalance in women. Conclusion: We came to the conclusion that thyroid hormone contributes to endometriosis because endometrial cells are sensitive to changes in TSH. The thyroid gland and its related hormone concentrations described a varied picture between healthy subjects and patients of endometriosis. Moreover, thyroid hormones and estrogen are found to play their significant roles in the disease.

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endometriosis

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