Elevated Levels of CA-125, Estradiol and Cortisol as Prominent Markers to Diagnose Various Stages of Endometriosis

Ashish Ashish, Kusum, Sangeeta Rai, Bhupendra Kumar, Radha Chaube, Royana Singh
In: JOURNAL OF SCIENTIFIC RESEARCH · 2021 · vol. 65(05) , pp. 50–55 · doi:10.37398/jsr.2021.650507 · W3203115924
article OA: bronze CC0 ⤵ 1 in-corpus citation
🔓 Open OA copy View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-11 ⓘ

This study found that elevated levels of CA-125, estradiol, and cortisol are associated with endometriosis progression and may serve as diagnostic markers for its various stages.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Endometriosis is a chronic inflammatory disease condition that affects an estimated 176 million women worldwide. The disease causes unbearable symptoms of pelvic pain and infertility that limits the quality of reproductive life of affected women. An attempt has been made to identify certain physiological and hormonal factors that may behave as reliable diagnostic markers to assess the various stages of endometriosis. It is a retrospective population-based study. Here a questionnaire-based study was conducted on females of Eastern Uttar Pradesh and Bihar that were suffering from endometriosis. Prevalent patients were characterized in terms of their socio-demographic and clinical characteristics, including the validated infertility and chronic disease registries. Progression of the disease was not found to be affected by age and body mass index (BMI) of subjects. Concentration of blood sugar (fasting and PP), and levels of serum luteinizing hormone (LH), follicle stimulating hormone (FSH), T4 and Thyroid stimulating hormone (TSH) did not change as disease progressed from stage 1 to 4. However, levels of serum estradiol, cortisol, prolactin, T3 and CA-125 increased as endometriosis progressed. There also existed a close association between CA-125, estradiol, cortisol and stages of endometriosis. Elevated levels of CA-125, estradiol and cortisol may behave as prominent diagnostic markers to assess progression of disease and to discriminate between various stages of endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosisinfertility

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (30)

Cited by (1)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK