Spontaneous and induced synthesis of cytokines by peripheral blood monocytes in patients with endometriosis

D P Braun, Braun DP, Donald P. Braun, Howard M. Gebel, Gebel H, H Gebel, R House, House R, Robert V. House, N Rana, Nasir Rana, Rana N, N P Dmowski, Dmowski NP, W. Paul Dmowski
Fertility and sterility · 1996 · vol. 65(6) , pp. 1125–1129 · doi:10.1016/s0015-0282(16)58325-3 · PMID:8641484 · W2242098259
Other OA: closed CC0 ⤵ 77 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Peripheral blood monocytes from women with endometriosis spontaneously produce higher levels of IL-6, TNF-alpha, and IL-1 beta, and show an enhanced response to LPS stimulation.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To investigate the capacity of peripheral blood monocytes (PBM) from women with endometriosis to secrete tumor necrosis factor-alpha (TNF-alpha), interleukin (IL) IL-6, IL-8, and IL-10. DESIGN: Peripheral blood monocytes were cultured in the presence and absence of lipopolysaccharide for 24 hours before assessment of cytokines in supernatants by enzyme immunoassay. SETTING: Institute for the Study and Treatment of Endometriosis and university-based research laboratories. PATIENTS AND PARTICIPANTS: Fertile controls, n - 10; women with endometriosis, n = 20. INTERVENTIONS: None. RESULTS: Basal synthesis of TNF-alpha, IL-6, and IL-8 and the lipopolysaccharide-stimulated synthesis of TNF-alpha by PBM from women with endometriosis was significantly greater in comparison to that of fertile controls. Endometriosis had no effect on the basal or stimulated synthesis of IL-10. CONCLUSIONS: These data show that endometriosis is associated with increased basal and stimulated synthesis and secretion of several different cytokines by PBM. Each of the cytokines found to be affected has the capacity to play a role in the symptomatology or pathogenesis of the disease.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Cytokines Endometriosis Monocytes Cytokines Cytokines Endometriosis Endometriosis Female Female Humans Humans Interleukin-10 Interleukin-10 Interleukin-10 Interleukin-6 Interleukin-6 Interleukin-6 Interleukin-8 Interleukin-8 Interleukin-8

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (32)

Cited by (50)

Source provenance

europepmc
last seen: 2026-10-13T06:10:10.580696+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:59:43.143194+00:00
unpaywall
last seen: 2026-10-09T06:36:44.367587+00:00
License: CC0 · commercial use OK