Impaired Development of Early Endometriotic Lesions in CD44 Knockout Mice

Jennifer F Knudtson, Rajeshwar R Tekmal, Marlen Tellez Santos, Peter Binkley, Peter A Binkley, Naveen Krishnegowda, Naveen K. Krishnegowda, Philip T. Valente, Philip Valente, Robert S Schenken
Reproductive sciences (Thousand Oaks, Calif.) · 2015 · vol. 23(1) , pp. 87–91 · doi:10.1177/1933719115594022 · PMID:26169039 · W825338681
article OA: closed CC0 ⤵ 11 in-corpus citations
Limited metadata. Only one source feed has indexed this record so far — no abstract, full text, or open-access copy is available through Endo Lab. The publisher's page (linked below) is the canonical location for the actual content. If you have institutional access, use "Find at my library".
View at publisher → View on OpenAlex View on PubMed
⚙ AI-generated summary by claude@2026-06+body, 2026-06-06 ⓘ

Early endometriotic lesions were reduced when either donor or recipient mice lacked CD44 expression, indicating CD44's role in both endometrial and peritoneal cells.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

The study investigated the role of the CD44–hyaluronan (HA) interaction in forming early endometriotic lesions using a murine endometriosis model. Endometrial tissue from wild-type or CD44 knockout donor mice was transplanted into recipient mice with either normal or CD44-deficient genotypes, and early lesions were quantified by fluorescent microscopy and confirmed by hematoxylin and eosin staining. Early endometriotic lesions were significantly reduced when either the donor endometrium lacked CD44 (in wild-type recipients) or when the recipient peritoneal environment lacked CD44 (in CD44 knockout recipients), with similar reductions when both peritoneal and endometrial tissues were CD44-negative; the authors explicitly conclude that both endometrial cell and peritoneal mesothelial cell CD44 contribute. This paper is centrally about endometriosis — it shows impaired development of early endometriotic lesions in CD44 knockout mice.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Hyaluronan Receptors Peritoneal Diseases Peritoneum Animals Disease Models, Animal Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Hyaluronan Receptors Hyaluronan Receptors Hyaluronic Acid Hyaluronic Acid Mice Mice, Knockout Peritoneal Diseases

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (19)

Cited by (11)

Source provenance

europepmc
last seen: 2026-06-13T06:22:48.782012+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:17:46.044120+00:00
License: CC0 · commercial use OK