Pathogenesis
This review examines historical theories on the histogenesis of endometriotic lesions and current evidence implicating immune system components in the disease's pathophysiology.
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This 1997/2008 review paper examines competing hypotheses for the pathogenesis of endometriosis, noting that no single theory accounts for all cases and that multiple mechanisms likely contribute. It first reviews evidence on different aspects of the histogenesis of endometriotic lesions and then highlights newer findings implicating components of the immune system in disease development, including macrophages and natural killer cells, as well as cytokine-related pathways. A key limitation is that the discussion is a synthesis of prior studies rather than new experimental data, and it does not establish a unified mechanism. This paper is centrally about endometriosis — it reviews histogenesis theories and immune-system factors (macrophages, natural killer cells, cytokines) implicated in its pathogenesis.
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Cited by (23)
- Identification of immune- and autophagy-related genes and effective diagnostic biomarkers in endometriosis: a bioinformatics analysis 2022
- CD44 variant 6 is involved in the attachment and invasion of endometrial cells to peritoneum 2020
- Epidemiological and Clinical Risk Factors for Endometriosis 2017
- Impaired Development of Early Endometriotic Lesions in CD44 Knockout Mice 2015
- Rotating nightshift work and the risk of endometriosis in premenopausal women 2011
- A prospective study of body size during childhood and early adulthood and the incidence of endometriosis 2010
- Adolescent Physical Activity and Endometriosis Risk 2009
- Adult Physical Activity and Endometriosis Risk 2009
- Chapter 10 Endometriosis and Autoimmunity 2008
- REVIEW ARTICLE: Immunopathogenesis of Pelvic Endometriosis: Role of Hepatocyte Growth Factor, Macrophages and Ovarian Steroids 2008
- Natural hair color and the incidence of endometriosis 2006
- ENDOMETRIOSE 2006
- Elevated levels of macrophage migration inhibitory factor in the peripheral blood of women with endometriosis 2005
- Peritoneal fluid cytokines and sICAM-1 in minimal endometriosis: search for discriminating factors between infertility and/or endometriosis 2005
- In utero exposures and the incidence of endometriosis 2004
- Reproductive History and Endometriosis Among Premenopausal Women 2004
- The epidemiology of endometriosis 2003
- Estradiol and Interleukin-1β Exert a Synergistic Stimulatory Effect on the Expression of the Chemokine Regulated upon Activation, Normal T Cell Expressed, and Secreted in Endometriotic Cells 2002
- Soluble interleukin-1 receptor type II blocks monocyte chemotactic protein-1 secretion by U937 cells in response to peripheral blood serum of women with endometriosis 2002
- Decreased Expression of the Decoy Interleukin-1 Receptor Type II in Human Endometriosis 2001
- Effect of hormonal agents on monocyte chemotactic protein-1 expression by endometrial epithelial cells of women with endometriosis 2000
- Apoptosis and Ki-67 Expression in Adenomyotic Lesions and in the Corresponding Eutopic Endometrium 1999
- Whole explants of peritoneum and endometrium: a novel model of the early endometriosis lesion 1999
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