Expression of CD44 in endometrial stromal cells from women with and without endometriosis and its effect on the adherence to peritoneal mesothelial cells

Yun Hee Koo, Yong Jin Na, Mee Young Ahn, Han Na Jeon, Jung In Yeom, Kyu Sup Lee
Obstetrics & gynecology science · 2013 · vol. 56(2) , pp. 102 · doi:10.5468/ogs.2013.56.2.102 · PMID:24327988 · PMC3784094 · W1973286269
article OA: gold CC0 ⤵ 4 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found no significant difference in CD44 expression or endometrial stromal cell adherence to mesothelial cells between women with and without endometriosis, suggesting CD44 is not directly involved in this adherence.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This paper studied whether CD44 expression in endometrial stromal cells (ESCs) differs between women with endometriosis and controls and whether CD44 contributes to ESC adherence to peritoneal mesothelial cells using a peritoneal mesothelial cell adhesion assay plus RT-PCR and Western blot for CD44 mRNA and protein. ESCs from 13 surgically confirmed endometriosis patients and 13 control women (hysterectomy for benign gynecologic disease/cervical carcinoma in situ without gross endometriosis) were compared, and ESC–mesothelial binding was tested with anti-CD44 antibody and with peritoneal fluid from endometriosis or control groups. CD44 mRNA and protein levels in ESCs and their baseline binding to peritoneal mesothelial cells did not significantly differ between groups, and anti-CD44 antibody reduced CD44 protein in both groups without changing adherence. In contrast, treating ESCs with peritoneal fluid from endometriosis patients increased ESC binding to peritoneal mesothelial cells specifically in the endometriosis group, with the main limitation being the small sample size and in vitro experimental nature. This paper is centrally about endometriosis — it specifically tests CD44 expression in ESCs from women with endometriosis and evaluates how that relates to ESC adherence to peritoneal mesothelial cells.

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Abstract

OBJECTIVE: This study was performed to compare the expression of CD44 in endometrial stromal cells (ESCs) of women with and without endometriosis and to evaluate the role of CD44 in the adherence of ESCs to peritoneal mesothelial cells (PMCs). METHODS: A PMC adherence assay was performed to evaluate the adherence of ESCs to PMCs in women with and without endometriosis. The expression of CD44 mRNA was measured by reverse transcription-polymerase chain reaction. CD44 protein was evaluated by Western blot analysis. RESULTS: There were no significant differences in the expression of CD44 mRNA and protein in ESCs or in the binding of ESCs to PMCs between patients with endometriosis and controls. Although the expression of CD44 protein was decreased in both women with endometriosis and controls after anti-CD44 antibody treatment, there was no effect on binding of ESCs to PMCs. Treatment of ESCs with peritoneal fluid from endometriosis patients resulted in a significant increase in binding of ESCs to PMCs compared to untreated ESCs in the endometriosis group. CONCLUSION: This study demonstrates that the expression of CD44 protein in ESCs from women with endometriosis might not be directly associated with adherence to PMCs.

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endometriosis

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