Иммунологические аспекты эндометриоза: обзор литературы

In: Лечащий Врач, Vol 0, Iss 4 (2021) · 2020 · pp. 37 · doi:10.26295/os.2020.29.10.007 · W3208498921
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This review synthesizes current understanding of endometriosis pathogenesis, focusing on vascularization mechanisms, immune factor contributions, hormone roles, immune cells, and cytokine involvement in lesion formation.

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В обзоре литературы рассматриваются современные представления о патогенезе эндометриоза с акцентом на механизмы васкуляризации очагов поражения и вклад иммунных факторов, а также обсуждается роль гормонов, иммунных клеток и цитокинов в формировании заболевания и варианты фармакологической терапии. Автор(ы) связывают иммунные и гормональные влияния с процессами ангиогенеза/васкулогенеза (включая роль VEGF и регуляцию его экспрессии стероидами и гипоксией) и приводят данные из экспериментальных и клинических работ, посвящённых клеточным и молекулярным участникам очага. В качестве ограничения обзорного формата не проводится собственный системный отбор или количественная мета-оценка исследований, а представление сведений основано на выбранной литературе, суммируемой авторами. Эта статья является обзором, который напрямую фокусируется на иммунологических аспектах эндометриоза и механизмах формирования очагов, включая васкуляризацию — то есть по сути о эндометриозе. This paper is centrally about endometriosis — it focuses on immunological mechanisms and the angiogenesis/vasculogenesis processes that support lesion formation.

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Abstract

Обзор направлен на то, чтобы свести воедино современное понимание патогенеза эндометриоза с особым акцентом на механизмы, лежащие в основе васкуляризации очагов поражения, и вклад иммунных факторов в формирования очага эндометриоза. Также проведен обзор роли гормонов, иммунных клеток и цитокинов в формировании эндометриоза и варианты фармакологической терапии.
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Иммунологические аспекты эндометриоза: обзор литературы https://doi.org/10.26295/OS.2020.29.10.007 Аннотация Обзор направлен на то, чтобы свести воедино современное понимание патогенеза эндометриоза с особым акцентом на механизмы, лежащие в основе васкуляризации очагов поражения, и вклад иммунных факторов в формирования очага эндометриоза. Также проведен обзор роли гормонов, иммунных клеток и цитокинов в формировании эндометриоза и варианты фармакологической терапии. Ключевые слова Об авторах Л. В. АдамянРоссия К. Н. Арсланян Россия О. Н. Логинова Россия Л. М. Манукян Россия Э. И. Харченко Россия Список литературы 1. Cramer D. W., Missmer S. A. The epidemiology of endometriosis // Annals of the New York Academy of Sciences. 2002; 955:11-22, 34-36, 396-406. 2. Dunselman G. A. J., Vermeulen N., Becker C., et al. ESHRE guideline: management of women with endometriosis // Human Reproduction. 2014; 29 (3): 400-412. DOI: 10.1093/humrep/det457. 3. Keettel W. C., Stein R. J. 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Regulation of monocyte chemotactic protein-1 expression in human endometrial stromal cells by estrogen and progesterone // Biology of Reproduction. 1999; 61 (1): 85-90. DOI: 10.1095/biolreprod61.1.85. Рецензия Для цитирования: Адамян Л.В., Арсланян К.Н., Логинова О.Н., Манукян Л.М., Харченко Э.И. Иммунологические аспекты эндометриоза: обзор литературы. Лечащий Врач. 2020;(4):37. https://doi.org/10.26295/OS.2020.29.10.007 For citation: Adamyan L.V., Arslanyan K.N., Loginova O.N., Manukyan L.M., Kharchenko E.I. Immunological aspects of endometriosis: review of the literature. Lechaschi Vrach. 2020;(4):37. (In Russ.) https://doi.org/10.26295/OS.2020.29.10.007 JATS XML

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