Is granulocyte colony-stimulating factor level predictive for human IVF outcome?

Ali Salmassi, A Salmassi, A G Schmutzler, Andreas Schmutzler, S Schaefer, K Koch, J Hedderich, W Jonat, Liselotte Mettler, L Mettler
Human Reproduction · 2005 · vol. 20(9) , pp. 2434–2440 · doi:10.1093/humrep/dei071 · PMID:15890733 · W2170420267
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Abstract

BACKGROUND: We investigated granulocyte colony-stimulating factor (G-CSF) in human reproduction. METHODS: From a total sample of 93 patients, we analysed in group 1 (n = 82) the level of G-CSF and estradiol (E(2)) in serum and follicular fluid (FF) on day of follicular puncture (FP). Furthermore, in response to ovarian stimulation, G-CSF levels in serum were compared between low (n = 11), moderate (n = 53) and high (n = 18) response patients. In group 2 (n = 23) serum for G-CSF assessment was collected throughout menstrual cycle until gestation. Group 3 (n = 11) patients with endometriosis were assessed for G-CSF in serum and FF on day of FP without further differentiation. RESULTS: G-CSF in FF was higher than in serum (P < 0.01). G-CSF in serum increased from low through moderate to high response (P < 0.001); pregnancy rates were 0, 24.5 and 33.5% respectively. G-CSF in serum increased throughout stimulation, reached a peak with ovulation induction (P = 0.01) and decreased until embryo transfer (P=0.001). G-CSF level only in pregnant patients (n = 11) increased from embryo transfer to implantation to gestation (P = 0.005). In endometriosis patients G-CSF in serum and FF was lower than in non-endometriosis patients (P < or = 0.03) and corresponded with low response patients. CONCLUSIONS: G-CSF is involved in follicle development and may be a predictor of IVF outcome.

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Condition tags

endometriosis

MeSH descriptors

Fertilization in Vitro Granulocyte Colony-Stimulating Factor Infertility, Female Infertility, Female Pregnancy Outcome Adult Biomarkers Biomarkers Biomarkers Endometriosis Endometriosis Female Follicle Stimulating Hormone Follicle Stimulating Hormone Follicular Fluid Follicular Fluid Granulocyte Colony-Stimulating Factor Granulocyte Colony-Stimulating Factor Humans Infertility, Female

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