Role of granulocyte colony-stimulating factor in human reproduction

Elham Naghshineh, Maryam Eftekhar, Parisa Khani
Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2018 · vol. 23(1) , pp. 7 · doi:10.4103/jrms.jrms_628_17 · PMID:29456564 · PMC5813296 · W2793926872
review OA: gold CC0 ⤵ 3 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review summarizes the multifaceted roles of granulocyte colony-stimulating factor in human reproduction, including ovulation, endometrial receptivity, and improving pregnancy loss.

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Abstract

As new research reveals, granulocyte colony-stimulating factor (G-CSF) plays an effective role in pregnancy success, considering that it not only affects the embryo implantation and ovarian function but also it promotes endometrial thickening and improves the pathophysiology of endometriosis, which all fundamentally lead to reducing pregnancy loss. In this review, we focus on the role of G-CSF in human reproduction. We summarized its role in ovulation, luteinized unruptured follicle syndrome, poor responders, improving repeated in vitro fertilization failure, endometrial receptivity and treatment of thin endometrium, and recurrent spontaneous abortion.

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endometriosis

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