Effect of intrauterine granulocyte-colony stimulating factor administration on in vitro fertilization outcome in women with moderate-to-severe endometriosis: An RCT

Ladan Kashani, Ashraf Moini, Tayebeh Esfidani, Nazila Yamini, Shima Mohiti
International journal of reproductive biomedicine · 2021 · vol. 19(8) , pp. 733–740 · doi:10.18502/ijrm.v19i8.9621 · PMID:34568734 · PMC8458918 · W3196849489
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Intrauterine granulocyte-colony stimulating factor administration did not significantly improve clinical pregnancy rates in infertile women with moderate-to-severe endometriosis undergoing in vitro fertilization.

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Abstract

BACKGROUND: Nearly 25-50% of infertile women have endometriosis. There are reports of disorders in the expression of granulocyte colony-stimulating factor (G-CSF) receptors in women with endometriosis. OBJECTIVE: To examine the effect of intrauterine administration of G-CSF in in vitro fertilization (IVF) cycles on the fertility rate of infertile women with moderate-to-severe endometriosis. MATERIALS AND METHODS: This clinical trial was conducted on 66 infertile women with moderate-to-severe endometriosis, undergoing IVF and intracytoplasmic sperm injection (ICSI). The participants were allocated into two groups via simple randomization: the G-CSF (n = 27) and control (n = 39) groups. In the G-CSF intervention group, on the oocyte pick-up day, immediately after an ovarian puncture, 300 μg of G-CSF was injected through a transcervical catheter under abdominal ultrasound guide to visualize flushing into the uterine cavity. Women in the control group received no intervention. The two groups were evaluated for clinical pregnancy. RESULTS: No significant difference was noted in the demographic characteristics of the two groups. The rate of clinical pregnancy was 28.2% in the control group and 25.9% in the G-CSF group, indicating no significant difference (p = 0.83). CONCLUSION: The results showed that the intrauterine injection of G-CSF had no effects on pregnancy in women with stage-3/4 endometriosis undergoing IVF.
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Publication International Journal of Reproductive BioMedicine (IJRM) Record type Journal article Published 9 September 2021 Authors Ladan Kashani | Ashraf Moini | Tayebeh Esfidani | Nazila Yamini | Shima Mohiti The publisher of this work supports multiple resolution. The work is available from the following locations: {'doi': '10.18502/ijrm.v19i8.9621', 'member_id': '7770', 'member': 'Knowledge E DMCC', 'container-title': 'International Journal of Reproductive BioMedicine (IJRM)', 'primary-resource': 'https://knepublishing.com/index.php/ijrm/article/view/9621', 'tld': 'knepublishing.com', 'clearbit-logo': '/static/no_logo.svg', 'coaccess': [], 'multiple-resolution': [{'url': 'http://journals.ssu.ac.ir/ijrmnew/article-1-1992-en.html', 'tld': 'ssu.ac.ir', 'clearbit-logo': '/static/no_logo.svg'}, {'url': 'https://knepublishing.com/index.php/ijrm/article/view/9621', 'tld': 'knepublishing.com', 'clearbit-logo': '/static/no_logo.svg'}], 'type': 'JOURNAL ARTICLE', 'published_date': '9 September 2021', 'publication': 'International Journal of Reproductive BioMedicine (IJRM)', 'title': 'Effect of intrauterine granulocyte-colony stimulating factor administration on in vitro fertilization outcome in women with moderate-to-severe endometriosis: An RCT', 'name': None, 'id': None, 'location': None, 'display_doi': 'https://doi.org/10.18502/ijrm.v19i8.9621', 'grant_info': None, 'grant_info_funders': None, 'grant_info_funder_ids': '', 'grant_info_type': None, 'multiple_lead_investigators': [], 'multiple_co_lead_investigators': [], 'multiple_investigators': [], 'finances': [], 'project_description': None, 'award_amount': None, 'award_start': None, 'funding_scheme': None, 'internal_award_number': None, 'editors': None, 'authors': 'Ladan Kashani | Ashraf Moini | Tayebeh Esfidani | Nazila Yamini | Shima Mohiti', 'chairs': None, 'supplementary_ids': None} https://doi.org/10.18502/ijrm.v19i8.9621 JSON XML

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