Determination of cathepsins B, D and G concentration in eutopic proliferative endometrium of women with endometriosis by the surface plasmon resonance imaging (SPRI) technique

Piotr Laudanski, Piotr Laudański, Ewa Gorodkiewicz, Gorodkiewicz E, Barbara Ramotowska, Ramotowska B, Radosław Charkiewicz, Mariusz Kuzmicki, Mariusz Kuźmicki, Jacek Szamatowicz
European journal of obstetrics, gynecology, and reproductive biology · 2013 · vol. 169(1) , pp. 80–83 · doi:10.1016/j.ejogrb.2013.01.024 · PMID:23466190 · W2063372654
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This study quantified cathepsins B, D, and G concentrations in eutopic proliferative endometrium from women with endometriosis using surface plasmon resonance imaging.

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Abstract

ObjectiveTo determine the concentrations of cathepsins B, D and G in proliferative eutopic endometrium of patients with and without endometriosis, by use of the surface plasmon resonance imaging (SPRI) technique.Study designA total of 55 patients were recruited in the study: 31 patients with endometriosis (stages I-IV) and 24 controls. Endometrial samples were obtained in the first phase of the menstrual cycle from regularly menstruating premenopausal women, prior to laparoscopy, by the use of aspiration biopsy. Endometriosis was appropriately classified according to the Revised American Fertility Society classification and confirmed by histopathology in every case. The SPRI technique was used to determine the concentration of cathepsins B, D and G. To compare the two groups for quantitative data, Mann-Whitney-Wilcoxon's test was used due to the non-normal distribution of the tested variables and normality of distribution was assessed using Shapiro-Wilk W test.ResultsThe concentration of the three examined cathepsins was higher in the proliferative eutopic endometrium of patients with endometriosis, especially in advanced stages, e.g. III and IV, when compared to healthy individuals. Corresponding median values were, for cathepsin B: [7.93 pmol/mg (min-max 2.82-15.71) vs 1.2 pmol/mg (min-max 0.7-15.49) p=0.0014], for cathepsin D: [1.86 pmol/mg (min-max 0.51-5.4) vs 1.03 pmol/mg (min-max 0.4-2.72) p=0.00041] and for cathepsin G: [0.6 pmol/mg (min-max 0.33-2.51) vs 0.3 pmol/mg (min-max 0.16-1.29) p=0.00051].ConclusionsIncreased concentrations of cathepsins B, D and G in the proliferative eutopic endometrium may play a role in the implantation of endometrial tissue outside the uterine cavity.

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Condition tags

endometriosis

MeSH descriptors

Cathepsin B Cathepsin D Cathepsin G Endometriosis Endometrium Adult Cathepsin B Cathepsin D Cathepsin G Endometriosis Endometriosis Endometrium Endometrium Female Humans Surface Plasmon Resonance

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