Therapeutic Efficacy of Catheter-directed Ethanol Sclerotherapy and Its Impact on Ovarian Reserve in Patients with Ovarian Endometrioma at Risk of Decreased Ovarian Reserve: A Preliminary Study

Jae Kyung Lee, So Hyun Ahn, Hye In Kim, Yong Jae Lee, Sunghoon Kim, Kichang Han, Man-Deuk Kim, Man Deuk Kim, Seok Kyo Seo
Journal of minimally invasive gynecology · 2021 · vol. 29(2) , pp. 317–323 · doi:10.1016/j.jmig.2021.08.018 · PMID:34469826 · W3196428918
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-10 ⓘ

Catheter-directed ethanol sclerotherapy reduced endometrioma size, dysmenorrhea pain, and CA-125 levels without significantly altering ovarian reserve as measured by AMH.

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This retrospective teaching-hospital study evaluated 18 patients with ovarian endometrioma ≥3 cm and preprocedural AMH <2 ng/mL to assess the therapeutic efficacy of catheter-directed ethanol sclerotherapy (CDS) and its impact on ovarian reserve. Using an 8.5-F catheter placed transabdominally or transvaginally into the cyst, aspiration was followed by 99% ethanol with 20-minute retention, with outcomes assessed by ultrasound and serum AMH/CA-125 and dysmenorrhea visual analog scale at baseline and 6 months. At 6 months, cyst size and CA-125 levels decreased significantly, dysmenorrhea scores improved in all patients, but AMH did not change significantly (p = .875). The main limitation is its small sample size and retrospective design, restricting the strength of inferences about ovarian reserve effects. This paper is centrally about endometriosis — specifically, catheter-directed ethanol sclerotherapy for ovarian endometrioma and its effect on ovarian reserve in patients at risk of decreased AMH.

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YUHASpace Repository 0 1033 Cited 0 times in Cited 12 times in Therapeutic Efficacy of Catheter-directed Ethanol Sclerotherapy and Its Impact on Ovarian Reserve in Patients with Ovarian Endometrioma at Risk of Decreased Ovarian Reserve: A Preliminary Study - Authors - Jae Kyung Lee ; So Hyun Ahn ; Hye In Kim ; Yong Jae Lee ; Sunghoon Kim ; Kichang Han ; Man-Deuk Kim ; Seok Kyo Seo - Citation - JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY, Vol.29(2) : 317-323, 2022-02 - Journal Title - JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY - ISSN - 1553-4650 - Issue Date - 2022-02 - Keywords - Antimüllerian hormone ; Decreased ovarian function ; Endometriosis ; Endometriotic cyst ; Minimally invasive procedure - Abstract - Study objective: To investigate the therapeutic efficacy of catheter-directed ethanol sclerotherapy (CDS) and its effect on ovarian reserve in patients with endometrioma at risk of decreased ovarian reserve. Design: Retrospective study. Setting: Teaching hospital. Patients: We evaluated 18 patients with ovarian endometrioma measuring ≥3 cm and preprocedural serum antimüllerian hormone (AMH) levels of <2 ng/mL. Interventions: An 8.5-F catheter was inserted either transabdominally or transvaginally into the endometrioma. After aspiration, sclerotherapy with 99% ethanol was performed, with a subsequent 20-minute ethanol retention. Measurements and main results: Ultrasonography was performed preprocedurally and 6 months after CDS to evaluate any recurrence or changes in cyst size. Furthermore, serum AMH levels, cancer antigen 125 (CA-125) levels, and the visual analog scale scores for dysmenorrhea were obtained to analyze the ovarian reserve and treatment efficacy, preprocedurally and at 6 months after CDS. The mean cyst size on ultrasonography and serum CA-125 levels decreased 6 months after CDS (p <.001 and p = .001, respectively). All patients reported a decreased visual analog scale score for dysmenorrhea (p <.001). However, the difference in serum AMH levels before and after CDS was statistically insignificant (p = .875). Conclusion: CDS was efficacious in reducing pain and serum CA-125 levels in patients with low AMH levels without adversely affecting their ovarian reserve. - Appears in Collections: - 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers 1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers - Yonsei Authors - Kim, Man Deuk(김만득) https://orcid.org/0000-0002-3575-5847 Kim, Sung Hoon(김성훈) https://orcid.org/0000-0002-1645-7473 Kim, Hye In(김혜인) https://orcid.org/0000-0001-7961-5988 Seo, Seok Kyo(서석교) https://orcid.org/0000-0003-3404-0484 Ahn, So Hyun(안소현) Lee, Yong Jae(이용재) https://orcid.org/0000-0003-0297-3116 Han, Ki Chang(한기창) https://orcid.org/0000-0002-9701-9757 Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Endometriosis Endometriosis Laparoscopy Ovarian Reserve Anti-Mullerian Hormone Catheters Ethanol Ethanol Female Humans Prospective Studies Retrospective Studies Sclerotherapy

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