A hollow MnO2 nanoplatform for multimodal imaging and NIR-triggered ablation of endometriosis through mitochondrial apoptosis and fibrosis

Lixia Li, Pan Liu, Nan Zhu, Zichong Gong, Hongyu He, Yanyan Zhou, Hui Duan, Mengdan Zhang, Qiang Su, Jiaqi Liu, Zhaoze Guo, Weihong Guo, Haihong Fang, Pengfei Li
In: Materials & Design · 2026 · vol. 265 , pp. 115956 · doi:10.1016/j.matdes.2026.115956 · W7148810348
article OA: gold CC0
🔓 Open OA copy View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Hollow manganese dioxide nanoplatforms target endometriosis lesions for multimodal imaging and NIR-triggered ablation via mitochondrial apoptosis and TGF-β1/Smad signaling.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

• Targeted delivery to endometriosis lesions was achieved via the EPR effect. • This nanoplatform integrates multimodal imaging with NIR-triggered therapy. • Its mechanism induces mitochondrial apoptosis and TGF-β1/Smad upregulation. Endometriosis is a common gynecological condition that significantly reduces quality of life and fertility in affected women. Despite being histologically benign, it displays biological behaviors reminiscent of malignancy, such as invasive growth within pelvic organs and the peritoneum. This study investigates a platform utilizing hollow manganese dioxide nanoparticles (HMnO 2 @IR820 NPs) engineered to concurrently delineate and ablate endometriosis lesions. This is accomplished through the integration of multimodal imaging, near-infrared (NIR) light-triggered photothermal therapy (PTT), and photodynamic therapy (PDT). Following intravenous administration, HMnO 2 @IR820 NPs preferentially accumulate in endometriosis lesions due to the enhanced permeability and retention effect. These nanoparticles facilitate effective multimodal imaging and lesion ablation for endometriosis. HMnO 2 @IR820 NPs induce mitochondrial damage and trigger the caspase-dependent apoptotic pathway, leading to apoptosis in primary endometrial stromal cells. In parallel, treatment with these nanoparticles activates the TGF-β1/Smad signaling pathway, promoting collagen fiber deposition. Animal experiments conducted on New Zealand rabbits have further demonstrated that HMnO 2 @IR820 NPs exhibit targeted properties for various types of endometriosis lesions, enhancing the precision of diagnosis and synergistic PDT & PTT of the disease. In conclusion, HMnO 2 @IR820 NPs represent a promising multifunctional nanotheranostic platform, facilitating multimodal imaging and NIR light-induced ablation of endometriosis through mitochondrial apoptosis and profibrotic effects.

My notes (saved in your browser only)

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (19)

Source provenance

openalex
last seen: 2026-06-18T06:08:43.033632+00:00
License: CC0 · commercial use OK