[Association of human leukocyte antigen-DQA1 with endometriosis of women in southern China].
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This study identified HLA-DQA1 * 0401 as a potentially susceptible gene and HLA-DQA1 * 0301 as a potentially protective gene for endometriosis in southern Chinese women.
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Abstract
OBJECTIVE: To study the genetic susceptibility in patients with endometriosis by genotyping their human leukocyte antigen-DQA1 (HLA-DQA1) alleles. METHODS: The allelic types of HLA-DQA1 were detected by polymerase chain reaction single specific primers (PCR-SSP) technique in 51 patients with endometriosis proven by laparoscopy or histological examination, and 44 control women who had laparoscopic sterilization and without endometriosis. RESULTS: The frequency of HLA-DQA * 0401 allele (12%) in patients with endometriosis group was markedly higher than that in the control group (0%) (P = 0.019). Contrarily, the frequency of HLA-DQA1 * 0301 allele (39%) in control group was higher than that in endometriosis group (14%) (P = 0.005, odds ratio = 0.253). CONCLUSION: Our result indicated that HLA-DQA1 * 0401 may be a susceptible gene in correlation with endometriosis, whereas HLA-DQA1 * 0301 may be a protective gene against endometriosis.
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Cited by (4)
- The link between immunity, autoimmunity and endometriosis: a literature update 2018
- Killer cell immunoglobulin-like receptors (KIR) and human leukocyte antigen-C (HLA-C) allorecognition patterns in women with endometriosis 2020
- Susceptibility to ovarian endometriosis in Polish population is not associated with HLA-DRB1 alleles 2005
- Auto-immunity and endometriosis 2021
Cited by (4)
- Auto-immunity and endometriosis 2021
- Killer cell immunoglobulin-like receptors (KIR) and human leukocyte antigen-C (HLA-C) allorecognition patterns in women with endometriosis 2020
- The link between immunity, autoimmunity and endometriosis: a literature update 2018
- Susceptibility to ovarian endometriosis in Polish population is not associated with HLA-DRB1 alleles 2005
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- europepmc
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- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-05-13T22:13:19.284922+00:00
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