The effect of an elimination diet on the functional state of the gastrointestinal tract and liver of childbearing age women having symptomatic adenomyosis

and methods. 120 women with symptomatic adenomyosis were divided into 4 groups: the Group I - 30 women who were treated with dienogest; the Groups ІІ, ІІІ and IV - 30 women each, who were prescribed an elimination diet taking into account the identified type of food intolerance. A comprehensive clinical examination, coprological examination, and ultrasound steatometry of the liver were performed. Statistical data was processed by the SPSS 21 program. Results. Compared with women of the Group I, patients of the Groups II, III, and IV showed a decrease in the pain symptoms of adenomyosis, the frequency of complaints from the digestive tract, amylorrhea, steatorrhea in feces, and markers of the inflammatory process in the intestine, as well as the frequency and severity of liver steatosis. Conclusions. The elimination diet, taking into account the identified type of food intolerance, has a positive effect on well-being, the functional state of the gastrointestinal tract and reduces the symptoms of the disease of childbearing age women with adenomyosis. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the author.

American Fertility Society. (1985). Revised American Fertility Society classification of endometriosis. Fertil Steril. 43 (3): 35-352. https://doi.org/10.1016/S0015-0282(16)48430-X; PMid:3979573 Barrier BF. (2010). Immunology of endometriosis. Clin Obstet Gynecol. 53 (2): 397-402. https://doi.org/10.1097/GRF.0b013e3181db7c33; PMid:20436316 Dynnik OB, Fedusenko AA, Kobilyak NN, Linskaya AV. (2016). 6 Measurements Ultrasonography of Diffuse Liver Disease or Multiparametric Ultrasound. Promeneva diahnostyka, promeneva terapiia. 3-4: 69-84. Eisenberg VH, Zolti M, Soriano D. (2012, Sep). Is there an association between autoimmunity and endometriosis? Autoimmun Rev. 11(11): 806-814. https://doi.org/10.1016/j.autrev.2012.01.005; PMid:22330229 Kanzaki M, Nakajima T, Yoshimura T. (2011). Immunological aspects of endometriosis. Clin Med. 59 (1): 44-47. Kennedy S, Bergqvist A, Chapron C, d'Hooghe T, Dunselman G, Greb R et al. (2005). ESHRE guideline for the diagnosis and treatment of endometriosis. Hum Reprod. 20 (1): 2698-2704. https://doi.org/10.1093/humrep/dei135; PMid:15980014 Marziali M, Capozzolo T. (2015). Role of Gluten-Free Diet in the Management of Chronic Pelvic Pain of Deep Infiltrativy Endometriosis. Minim Invasive Gynecol. 22 (6S): S51-S52. https://doi.org/10.1016/j.jmig.2015.08.142; PMid:27679268 Naftalin J, Hoo W, Nunes N, Holland T, Mavrelos D, Jurkovic D. (2016). Association between ultrasound features of adenomyosis and severity of menstrual pain. Ultrasound Obstet Gynecol. 47(6): 779-783. https://doi.org/10.1002/uog.15798; PMid:26499878 Naftalin J, Hoo W, Pateman K, Mavrelos D, Holland T, Jurkovic D. (2012). How common is adenomyosis? A prospective study of prevalence using transvaginal ultrasound in a gynaecology clinic. Hum Reprod. 27(12): 3432-3439. https://doi.org/10.1093/humrep/des332; PMid:23001775 Peters M, Mikeltadze I, Karro H, Saare M et al. (2022). Endometriosis and irritable bowel syndrome: similarities and differences in the spectrum of comorbidities. Hum Reprod. 37 (9): 2186-2196. https://doi.org/10.1093/humrep/deac140; PMid:35713579 Sasso M, Miette V, Sandrin L, Beaugrand M. (2012). The controlled attenuation parameter (CAP): a novel tool for the noninvasive evaluation of steatosis using Fibroscan. Clin Res Hepatol Gastroenterol. 36(1): 13-20. https://doi.org/10.1016/j.clinre.2011.08.001; PMid:21920839 Sidell N, Han SW, Parthasarathy S. (2012). Regulation and modulation of abnormal immune responses in endometriosis. NY Acad Sci. 955: 159-173; discussion 199-200, 396-406. https://doi.org/10.1111/j.1749-6632.2002.tb02777.x; PMid:11949945 Suslikova LV, Serbeniuk AV, Lonshakova MS. (2021). Symptomatic endometriosis in women of fertile age through the prism of autoimmunization to food allergens (Literature review). Reproductive health of woman, 5 (50): 65-71. https://doi.org/10.30841/2708-8731.5.2021.240029 Upson K, Missmer SA. (2020). Epidemiology of Adenomyosis. Semin Reprod Med. 38 (2-3): 89-107. https://doi.org/10.1055/s-0040-1718920; PMid:33105509 PMCid:PMC7927213 Wei Y, Liang Y, Lin H, Dai Y, Yao S. (2020). Autonomic nervous system and inflammation interaction in endometriosis-associated pain. J Neuroinflammation. 17 (1): 80. https://doi.org/10.1186/s12974-020-01752-1; PMid:32145751 PMCid:PMC7060607 Yang F, Wu Y, Hockey R et al. (2023). Evidence of shared genetic factors in the etiology of gastrointestinal disorders and endometriosis and clinical implications for disease management. Cell Rep Med. 4 (11): 101250. https://doi.org/10.1016/j.xcrm.2023.101250; PMid:37909040 PMCid:PMC10694629 Zhang T, De Carolis C, Man GCW, Wang CC. (2018). The link between immunity, autoimmunity and endometriosis: a literature update. Autoimmun Rev. 17 (10): 945-955. https://doi.org/10.1016/j.autrev.2018.03.017; PMid:30107265 Downloads Published Issue Section License Copyright (c) 2024 Ukrainian Journal Health of Woman This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. The policy of the Journal UKRAINIAN JOURNAL «HEALTH OF WOMAN» is compatible with the vast majority of funders' of open access and self-archiving policies. The journal provides immediate open access route being convinced that everyone – not only scientists - can benefit from research results, and publishes articles exclusively under open access distribution, with a Creative Commons Attribution-Noncommercial 4.0 international license (СС BY-NC). Authors transfer the copyright to the Journal UKRAINIAN JOURNAL «HEALTH OF WOMAN» when the manuscript is accepted for publication. Authors declare that this manuscript has not been published nor is under simultaneous consideration for publication elsewhere. After publication, the articles become freely available on-line to the public. Readers have the right to use, distribute, and reproduce articles in any medium, provided the articles and the journal are properly cited. The use of published materials for commercial purposes is strongly prohibited.