Oxidative Stress Mediated by Macrophages Promotes Angiogenesis and Early Development of Endometriosis

Gene Chi Wai Man; Astrid Borchert; Tao Zhang; Sze Wan Hung; Loucia Kit-ying Chan; Loucia Kit‐Ying Chan; Hartmut Kühn; Chi Chiu Wang

doi:10.2139/ssrn.4786240

Oxidative Stress Mediated by Macrophages Promotes Angiogenesis and Early Development of Endometriosis

Gene Chi Wai Man, Astrid Borchert, Tao Zhang, Sze Wan Hung, Loucia Kit-ying Chan, Loucia Kit‐Ying Chan, Hartmut Kühn, Chi Chiu Wang

2024 · doi:10.2139/ssrn.4786240 · W4394697083

preprint OA: green CC0

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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Macrophages in endometriosis promote angiogenesis and early disease development through oxidative stress mechanisms.

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Condition tags

endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (54)

Aberrant Expression of Leptin in Human Endometriotic Stromal Cells Is Induced by Elevated Levels of Hypoxia Inducible Factor-1α via openalex
Analysis of follicular fluid and serum markers of oxidative stress in women with infertility related to endometriosis via openalex
Anti-angiogenic effects of green tea catechin on an experimental endometriosis mouse model via openalex
Co‐culture with macrophages enhances the clonogenic and invasion activity of endometriotic stromal cells via openalex
Different Expression of Hypoxic and Angiogenic Factors in Human Endometriotic Lesions via openalex
Evaluation of oxidative stress markers and intra-extracellular antioxidant activities in patients with endometriosis via openalex
Expression of Vascular Endothelial Growth Factor (VEGF), Hypoxia Inducible Factor-1α (HIF-1α), and Microvessel Density in Endometrial Tissue in Women With Adenomyosis via openalex
Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation via openalex
Hypoxia: The force of endometriosis via openalex
Immunobiology of endometriosis via openalex
Immunopathogenesis of endometriosis: An overview of the role of innate and adaptive immune cells and their mediators via openalex
Interferon‐Gamma (IFN‐γ) and Interleukin‐6 (IL‐6) in Peritoneal Fluid and Macrophage‐Conditioned Media of Women With Endometriosis via openalex
Lgr5 Does Not Vary Throughout the Menstrual Cycle in Endometriotic Human Eutopic Endometrium via openalex
Macrophage Migration Inhibitory Factor Antagonist Blocks the Development of Endometriosis In Vivo via openalex
Macrophages Are Alternatively Activated in Patients with Endometriosis and Required for Growth and Vascularization of Lesions in a Mouse Model of Disease via openalex
Macrophages inhibit and enhance endometriosis depending on their origin via openalex
Metastatic or Embolic Endometriosis, due to the Menstrual Dissemination of Endometrial Tissue into the Venous Circulation. via openalex
Oxidative stress and endometriosis via openalex
Oxidative stress biomarkers in patients with endometriosis: systematic review via openalex
Pathophysiology and Immune Dysfunction in Endometriosis via openalex
Prodrug of green tea epigallocatechin-3-gallate (Pro-EGCG) as a potent anti-angiogenesis agent for endometriosis in mice via openalex
Retrograde menstruation in healthy women and in patients with endometriosis. via openalex
Role of cytokines in endometriosis via openalex
The link between immunity, autoimmunity and endometriosis: a literature update via openalex
The Role of the Immune System in the Development of Endometriosis via openalex
Transcriptome meta-analysis reveals differences of immune profile between eutopic endometrium from stage I-II and III-IV endometriosis independently of hormonal milieu via openalex
Vascular endothelial growth factor C is increased in endometrium and promotes endothelial functions, vascular permeability and angiogenesis and growth of endometriosis via openalex
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[1] Aberrant Expression of Leptin in Human Endometriotic Stromal Cells Is Induced by Elevated Levels of Hypoxia Inducible Factor-1α via openalex

[2] Analysis of follicular fluid and serum markers of oxidative stress in women with infertility related to endometriosis via openalex

[3] Anti-angiogenic effects of green tea catechin on an experimental endometriosis mouse model via openalex

[4] Co‐culture with macrophages enhances the clonogenic and invasion activity of endometriotic stromal cells via openalex

[5] Different Expression of Hypoxic and Angiogenic Factors in Human Endometriotic Lesions via openalex

[6] Evaluation of oxidative stress markers and intra-extracellular antioxidant activities in patients with endometriosis via openalex

[7] Expression of Vascular Endothelial Growth Factor (VEGF), Hypoxia Inducible Factor-1α (HIF-1α), and Microvessel Density in Endometrial Tissue in Women With Adenomyosis via openalex

[8] Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation via openalex

[9] Hypoxia: The force of endometriosis via openalex

[10] Immunobiology of endometriosis via openalex

[11] Immunopathogenesis of endometriosis: An overview of the role of innate and adaptive immune cells and their mediators via openalex

[12] Interferon‐Gamma (IFN‐γ) and Interleukin‐6 (IL‐6) in Peritoneal Fluid and Macrophage‐Conditioned Media of Women With Endometriosis via openalex

[13] Lgr5 Does Not Vary Throughout the Menstrual Cycle in Endometriotic Human Eutopic Endometrium via openalex

[14] Macrophage Migration Inhibitory Factor Antagonist Blocks the Development of Endometriosis In Vivo via openalex

[15] Macrophages Are Alternatively Activated in Patients with Endometriosis and Required for Growth and Vascularization of Lesions in a Mouse Model of Disease via openalex

[16] Macrophages inhibit and enhance endometriosis depending on their origin via openalex

[17] Metastatic or Embolic Endometriosis, due to the Menstrual Dissemination of Endometrial Tissue into the Venous Circulation. via openalex

[18] Oxidative stress and endometriosis via openalex

[19] Oxidative stress biomarkers in patients with endometriosis: systematic review via openalex

[20] Pathophysiology and Immune Dysfunction in Endometriosis via openalex

[21] Prodrug of green tea epigallocatechin-3-gallate (Pro-EGCG) as a potent anti-angiogenesis agent for endometriosis in mice via openalex

[22] Retrograde menstruation in healthy women and in patients with endometriosis. via openalex

[23] Role of cytokines in endometriosis via openalex

[24] The link between immunity, autoimmunity and endometriosis: a literature update via openalex

[25] The Role of the Immune System in the Development of Endometriosis via openalex

[26] Transcriptome meta-analysis reveals differences of immune profile between eutopic endometrium from stage I-II and III-IV endometriosis independently of hormonal milieu via openalex

[27] Vascular endothelial growth factor C is increased in endometrium and promotes endothelial functions, vascular permeability and angiogenesis and growth of endometriosis via openalex

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