Ferroptosis: a novel pathway in the pathogenesis and treatment of endometriosis

As a common chronic disease, endometriosis (EMs) affects nearly 10% of women of childbearing age, may cause other complications such as infertility, and has a tendency to develop malignant tumors. Ferroptosis is a newly discovered apoptotic process characterized by intracellular free iron excess, which mediates Fenton reaction and eventually leads to lipid peroxidation in the cell membrane leading to cell death. The abnormal changes of intracellular iron concentration may lead to the accumulation of reactive oxygen species (ROS) and the imbalance of redox homeostasis, thus leading to the occurrence of iron death. At present, the pathogenesis and effect of iron death on EMs are not completely clear, and the study of its physiological and pathological mechanism is very important for its diagnosis and treatment. This article reviews the research progress of the occurrence and development of EMs in order to provide new ideas for the pathogenesis, diagnosis and treatment of EMs. Similar content being viewed by others

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Author information Authors and Affiliations Contributions Xunshu Cheng, Muhammad Azhar Memon and Waseem Ali: Conceptualization, Writing Original draft preparation, Yonggang Ma: Writing- Reviewing and Editing. Corresponding author Ethics declarations Competing interest The authors declare that there are no conflicts of interest. Rights and permissions Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. About this article Cite this article Cheng, X., Memon, M.A., Ali, W. et al. Ferroptosis: a novel pathway in the pathogenesis and treatment of endometriosis. J Mol Histol 56, 272 (2025). https://doi.org/10.1007/s10735-025-10499-z Received: Accepted: Published: Version of record: DOI: https://doi.org/10.1007/s10735-025-10499-z