Cardiovascular Implications of Gynecological Disorders: Bridging the Gap Between Gynecology and Cardiology

Ashish Kumar Tripathi, Ashish Tripathi, Sanjana Arsha, Anish Thapa, Sangharsha Thapa, Swati Chand, William H Frishman, Wilbert S Aronow
Cardiology in review · 2024 · doi:10.1097/crd.0000000000000759 · PMID:39078163 · W4401119425
article OA: closed CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Gynecological disorders including endometriosis, polycystic ovary syndrome, and gynecological cancers are linked to increased cardiovascular disease risk through shared mechanisms and treatment side effects.

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Abstract

Gynecological disorders such as endometriosis, polycystic ovary syndrome, and gynecological cancers are increasingly recognized as potential risk factors for cardiovascular disease (CVD). Endometriosis, a chronic inflammatory condition, exhibits shared pathogenic mechanisms with CVD, including endothelial dysfunction and an atherogenic lipid profile. Emerging evidence suggests a link between endometriosis and an elevated risk of cardiovascular events such as myocardial infarction, ischemic heart disease, and hypertension. Polycystic ovary syndrome, characterized by hormonal imbalances and metabolic derangements, is associated with an increased risk of hypertension, myocardial infarction, and structural cardiac abnormalities, even after controlling for obesity. Gynecological cancers, such as ovarian, endometrial, and cervical cancers, are also associated with an increased burden of cardiovascular comorbidities and mortality. Cancer treatments, including chemotherapy and radiation therapy, can further contribute to cardiovascular toxicity. Understanding the interplay between gynecological disorders and CVD is crucial for identifying high-risk individuals, implementing preventive strategies, and providing comprehensive care. A multidisciplinary approach involving gynecologists, cardiologists, and other specialists is essential for optimizing the management of these complex conditions and improving overall patient outcomes.

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endometriosis

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