Risk of major adverse cardiovascular and cerebrovascular events in Taiwanese women with endometriosis

Hsin-Ju Chiang, Chiang HJ, Hsin‐Ju Chiang, Kuo‐Chung Lan, Kuo-Chung Lan, Lan KC, Yao‐Hsu Yang, Yao-Hsu Yang, John Y. Chiang, Chiang JY, Fu-Tsai Kung, Fu‐Tsai Kung, Fu-Jen Huang, Huang FJ, Lin YJ, Yu-Ju Lin, Yu‐Ju Lin, Yu-Ting Su, Su YT, Pei‐Hsun Sung, Pei-Hsun Sung
Journal of the Formosan Medical Association = Taiwan yi zhi · 2020 · vol. 120(1) , pp. 327–336 · doi:10.1016/j.jfma.2020.10.005 · PMID:33268157 · W3094615877
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Taiwanese women with endometriosis had a higher frequency of comorbidities and an increased risk of major adverse cardiovascular and cerebrovascular events compared to the general population.

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Abstract

BACKGROUND/PURPOSE: Endometriosis (EM) is linked to cardiovascular disease (CVD). However, whether this finding can be applied to the Taiwanese population remained unanswered. To investigate the association between EM and major adverse cardiovascular and cerebrovascular events (MACCE) and the therapeutic effect on the risk of MACCE in Asian women with EM. A retrospective population-based cohort study was performed. METHODS: A total of 17 543 patients with EM aged between 18 and 50 years were identified from a general population of 1 million Taiwanese after excluding diagnoses of major CVD and cerebrovascular accident (CVA) prior to EM. The comparison group (n = 70 172) without EM was selected by matching the study cohort with age, sex, and income and urbanization levels in a 4:1 ratio. RESULTS: During a median follow-up period of 9.2 years, Taiwanese women with EM had a significantly higher frequency of comorbidities, medical and surgical treatment, and MACCE than did their non-EM counterparts (2.76% vs 2.18%, P < .0001). After adjustment for comorbidities, patients with EM had an approximately 1.2-fold increased risk of MACCE (95% CI 1.05-1.29; P = .0053) and a higher cumulative incidence of MACCE compared with the normal population. Neither medical nor surgical treatment increased the risk of MACCE. Furthermore, medical treatment for EM appeared to be protective against MACCE. CONCLUSION: Taiwanese women with EM not only had a substantially higher frequency of comorbidities but also an increased risk of MACCE compared with the general population.

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Condition tags

endometriosis

MeSH descriptors

Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cerebrovascular Disorders Cerebrovascular Disorders Cerebrovascular Disorders Endometriosis Endometriosis Endometriosis Adolescent Adult Cohort Studies Female Humans Middle Aged Retrospective Studies Risk Factors Young Adult

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