Increased risk of cardiovascular disease in women with endometriosis: A systematic review and meta-analysis

Saad M, Muhammad Saad, Ifrah Ansari, Ansari I, Imran Ansari, Ibrahim ZS, Zainab Siddiqua Ibrahim, Zeina Ibrahim, Batool RM, Rida Batool, Ruqiat Masooma Batool, Syed Ibad Ahsan, Muhammad Sameer Arshad, Arshad MS, Peter Collins, Collins P, Raheel Ahmed, Ahmed R
European journal of obstetrics, gynecology, and reproductive biology · 2025 · vol. 312 , pp. 114081 · doi:10.1016/j.ejogrb.2025.114081 · PMID:40450807 · W4410641491
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This meta-analysis of seven studies found that women with endometriosis have a significantly increased risk of cerebrovascular disease, ischemic heart disease, major adverse cardiovascular events, and arrhythmias.

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Abstract

BACKGROUND: The association between endometriosis and cardiovascular disease remains poorly understood. This study conducted a meta-analysis to evaluate the risk of adverse cardiovascular outcomes in women with endometriosis compared to those without the condition. METHODS: A comprehensive search of online databases was performed up to November 2024 to identify studies comparing adverse cardiovascular outcomes in women with and without endometriosis. A random-effects model was employed for the meta-analysis to calculate hazard ratios (HRs) with 95% confidence intervals (CIs). RESULTS: The meta-analysis included seven studies encompassing a total of 1,407,875 participants. Women with endometriosis demonstrated a significantly increased risk of cerebrovascular disease (HR: 1.19, 95 % CI: 1.13-1.24, p < 0.00001) and ischemic heart disease (HR: 1.35, 95 % CI: 1.32-1.39, p < 0.00001). Additionally, the risk of major adverse cardiovascular events (HR: 1.15, 95 % CI: 1.13-1.19, p < 0.00001) and arrhythmias (HR: 1.21, 95 % CI: 1.17-1.25, p < 0.00001) was significantly elevated. However, no significant associations were observed for heart failure or all-cause mortality. CONCLUSION: This meta-analysis indicates that women with endometriosis are at heightened risk for several cardiovascular conditions. These findings underscore the need for robust prospective studies to validate these associations and to explore underlying mechanisms.

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Condition tags

endometriosis

MeSH descriptors

Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (47)

Cited by (8)

Source provenance

europepmc
last seen: 2026-09-11T06:15:56.568227+00:00
openalex
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License: CC0 · commercial use OK