The impact of endometriosis on cardiovascular and cerebrovascular diseases: A Mendelian randomization study

Danyang Lu, Di Lü, Yisai Yang, Tiantian Yu
Women & health · 2025 · vol. 65(7) , pp. 582–593 · doi:10.1080/03630242.2025.2539819 · PMID:40728198 · W4412727460
article OA: closed CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This Mendelian randomization study found no robust causal link between endometriosis and major cardiovascular or cerebrovascular diseases, with unstable associations for atrial fibrillation requiring further validation.

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Abstract

= .045), this association was not robust. Sensitivity tests, including the "leave-one-out" analysis, showed the results to be unstable, and MR-weighted median analyses confirmed the lack of consistency in these findings. This MR study does not support a causal role of endometriosis in major cardiovascular or cerebrovascular diseases. The unstable association with AF may reflect residual pleiotropy or limited power, underscoring the need for validation in larger, diverse cohorts.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases Cardiovascular Diseases

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (50)

Cited by (1)

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