Interleukin-6 and soluble interleukin-6 receptor in peritoneal fluid and serum of patients with endometriosis.
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This study found elevated concentrations of IL-6 and soluble IL-6 receptor in the peritoneal fluid and serum of endometriosis patients compared to those with benign gynecologic conditions.
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Abstract
OBJECTIVE: Interleukin-6 (IL-6) and soluble Interleukin-6-receptor (sIL-6R) concentrations were investigated in patients with endometriosis and other benign gynecologic diseases. METHODS: During laparoscopy or laparotomy peritoneal fluid and serum were collected from 29 patients with endometriosis, 31 patients with benign ovarian masses and 4 patients with chronic inflammation or adhesions. Interleukin-6 (IL-6) concentrations were determined by Elisa-technique. RESULTS: Patients with endometriosis stage IV revealed slightly higher IL-6 concentrations in peritoneal fluid when compared to patients with stage I to II disease and ovarian masses/ chronic inflammation. IL-6 serum concentrations were higher in case of stage I and II when compared to stage III and IV and ovarian masses/chronic inflammation. Patients with endometriosis revealed significantly higher sIL-6 receptor concentrations in peritoneal fluid and serum as compared to patients with ovarian cysts and chronic inflammation. CONCLUSION: IL-6 and soluble IL-6 receptor may be considered to be involved in endometriosis. However, the patho-physiologic mechanism must be the subject of further investigation.
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Cited by (20)
- Inflammatory MicroRNAs and the Pathophysiology of Endometriosis and Atherosclerosis: Common Pathways and Future Directions Towards Elucidating the Relationship 2022
- Prospective Evaluation of a Panel of Plasma Cytokines and Chemokines as Potential Markers of Pelvic Endometriosis in Symptomatic Women 2016
- mRNA-Binding Protein TIA-1 Reduces Cytokine Expression in Human Endometrial Stromal Cells and Is Down-Regulated in Ectopic Endometrium 2014
- Krüppel-Like Factor 9 Deficiency in Uterine Endometrial Cells Promotes Ectopic Lesion Establishment Associated With Activated Notch and Hedgehog Signaling in a Mouse Model of Endometriosis 2014
- Antioxidant supplementation reduces endometriosis-related pelvic pain in humans 2012
- Peritoneal fluid proteome in women with different ASRM stages of endometriosis 2008
- Avaliação das concentrações das interleucinas 1-beta e 6 e da proteína amilóide A, no líquido peritoneal e no soro de pacientes com endometriose pélvica 2007
- Is Endometriosis Associated with Systemic Subclinical Inflammation? 2006
- Changes in cytokine levels of patients with ovarian endometriosis after treatment with gonadotropin-releasing hormone analogue, ultrasound-guided drainage, and intracystic recombinant interleukin-2 2005
- Macrophages are activated by 17b-estradiol: possible permission role in endometriosis 2004
- Immunology and Endometriosis 2003
- Analysis of an Interleukin-6 Gene Promoter Polymorphism in Women With Endometriosis Polymorphism in Women With Endometriosis By Pyrosequencing 2003
- Analysis of an interleukin-6 gene promoter polymorphism in women with endometriosis by pyrosequencing 2003
- Endometriosis in Reproductive Immunology 2002
- Identification of an Invasive, N-Cadherin-Expressing Epithelial Cell Type in Endometriosis Using a New Cell Culture Model 2001
- Immunobiology of endometriosis 2001
- E- and P-selectin expression in endometriotic tissues and the corresponding endometria 2000
- Elevated levels of interleukin-2, soluble interleukin-2 receptor alpha, interleukin-6, soluble interleukin-6 receptor and vascular endothelial growth factor in serum and ascitic fluid of patients with severe ovarian hyperstimulation syndrome 1999
- Pathogenesis of Endometriosis: The Role of Peritoneal Fluid 1999
- Endometriotic disease: the role of peritoneal fluid 1998
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