Characteristic and Regenerative Potential of Human Endometrial Stem Cells and Progenitors

Azin Ghamari, Faeze Daghigh, Alireza Mohebbi, Yekta Rahimi, Layla Shojaie, Masoumeh Majidi Zolbin
In: Stem cells: From Potential to Promise · 2021 · pp. 55–82 · doi:10.1007/978-981-16-0301-3_3 · W3202945026
book-chapter OA: closed CC0
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-10 ⓘ

Human endometrial stem cells reside in niches and possess mesenchymal stem cell-like properties, showing potential for regenerative therapies.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

The paper characterizes human endometrial stem cells and progenitors that may act as stem-cell niches supporting endometrial regeneration after menstruation, using evidence from clonogenic assays and identification of label-retaining and marker-defined cell populations. It reports that endometrial epithelial clonogenicity is well supported by TGFα, EGF, and PDGF-BB, while other tested factors were inadequately supportive and bFGF did not enhance epithelial clonogenicity; it also describes ~3% label-retaining epithelial and ~6% stromal cells in mouse endometrium and identifies CD146+ PDGF-Rβ+ human endometrial stem cells with MSC-like properties, including colony-forming stromal cells that differentiate into mesenchymal lineages and express MSC markers. The main caveat is that the evidence summarized includes both human and mouse data and variable experimental conditions supporting different progenitor behaviors. Relevance to endometriosis: the paper’s framing situates uterine stem cells within female reproductive tract disease pathogenesis, a context that directly intersects with endometriosis biology even though the chapter itself is focused on endometrial stem cell characteristics.

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last seen: 2026-06-10T17:14:06.276822+00:00
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