Expression of human b-defensin-2 in the eutopic and ectopic endometrial tissues in patients with endometriosis

Li YuanGang
2013 · W3147499459
article OA: closed CC0 Metadata only
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Human b-defensin-2, TNF-a, and IL-1b gene and protein expression were significantly higher in ectopic endometrium of endometriosis patients than in eutopic endometrium, suggesting a role in pathogenesis.

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Abstract

Objective To investigate the expression of human b-defensin-2 (hBD-2) in the endometrium of patients with endometriosis (EMS) and explore the potential role of hBD-2 in the pathogenesis of EMS. Design Prospective controlled study. Sample 50 women including EMS patients undergoing laparoscopic ovarian cystectomy and non-EMS patients undergoing hysterectomy for uterine fibroids. Setting Large university teaching hospital. Methods Patients were divided into EMS and non-EMS groups. The gene expressions of hBD-2, interleukin (IL)1b and tumor necrosis factor (TNF)-a in the endometrial tissues of each group were detected with real-time quantitative polymerase chain reaction (PCR), and hBD-2 protein expression with immunohistochemical method. Results The gene expression levels of hBD-2, TNF-a, and IL-1b as well as the positive expression rate of hBD-2 protein in the ectopic endometrium of EMS patients were significantly higher than those in the eutopic endometrium of EMS and non-EMS patients (all P 0.05). Correlation analysis showed that the gene expression levels of hBD-2 in the ectopic and eutopic endometrium of EMS patients were positively correlated with the gene expression levels of IL-1b and TNF-a (P 0.01). Conclusion High levels of hBD-2 gene and protein expressions in the ectopic endometrium of EMS patients may be an important contributor in the pathogenesis of EMS. TNF-a and IL-1b may promote the upregulation of hBD-2 expression.

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endometriosis

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