Danazol suppresses the production of interleukin-1 beta and tumor necrosis factor by human monocytes

Mori H, H Mori, Hidehiro Mori, Nakagawa M, M Nakagawa, Naoki Itoh, N Itoh, Itoh N, K Wada, KEISUKE WADA, Wada K, Teruhiko Tamaya, T Tamaya, Tamaya T
American journal of reproductive immunology (New York, N.Y. : 1989) · 1990 · vol. 24(2) , pp. 45–50 · doi:10.1111/j.1600-0897.1990.tb01037.x · PMID:2288648 · W1973553356
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Danazol dose-dependently suppressed interleukin-1β and tumor necrosis factor production by human monocytes, while estradiol and progesterone only enhanced it in some donors.

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Abstract

The effects of estradiol (E2), progesterone (P), and danazol on the production of interleukin-1 beta (IL-1 beta) and tumor necrosis factor (TNF) by OK-432 (a streptococcal preparation)-stimulated monocytes were examined. E2 and P at physiologic concentrations enhanced IL-1 beta and TNF production by monocytes from donors with lower control levels (without steroids added) of IL-1 beta and TNF. However, E2 and P at physiologic concentrations did not affect IL-1 beta and TNF production by monocytes from donors with higher control levels of IL-1 beta and TNF. Danazol inhibited IL-1 beta and TNF production by monocytes in a dose-dependent manner from not only donors with lower control levels of IL-1 beta and TNF but also donors with higher control levels of IL-1 beta and TNF. Danazol at a concentration of 10(-6) M significantly suppressed IL-1 beta and TNF production in the presence of E2 and/or P at concentrations giving peak responses of IL-1 beta production. These findings suggest possible new mechanisms of action for danazol in the treatment of endometriosis and infertility associated with immune abnormalities.

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Condition tags

endometriosisinfertility

MeSH descriptors

Danazol Interleukin-1 Monocytes Tumor Necrosis Factor-alpha Adult Adult Danazol Danazol Estradiol Estradiol Estradiol Female Female Humans Humans Interleukin-1 Interleukin-1 In Vitro Techniques In Vitro Techniques Lymphocyte Activation

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