Randomized controlled trial of superovulation and insemination for infertility associated with minimal or mild endometriosis

Tummon IS, Ian S. Tummon, I S Tummon, L J Asher, Linda J. Asher, Asher LJ, James S. Martin, Martin JS, J S Martin, Togas Tulandi, T Tulandi, Tulandi T
Fertility and sterility · 1997 · vol. 68(1) , pp. 8–12 · doi:10.1016/s0015-0282(97)81467-7 · PMID:9207576 · W2167895920
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This randomized controlled trial investigated whether superovulation and insemination improve pregnancy rates in women with minimal or mild endometriosis.

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Abstract

OBJECTIVE: To evaluate the efficacy of superovulation and IUI versus no treatment for infertility associated with minimal or mild endometriosis. DESIGN: Randomized trial. SETTING(S): London Health Sciences Centre, University Campus, The University of Western Ontario, London, Ontario; and Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada. PATIENT(S): Three hundred eleven cycles in 103 couples in whom minimal or mild endometriosis was the sole identified subfertility factor. INTERVENTION(S): Superovulation with FSH and IUI. MAIN OUTCOME MEASURE(S): Live birth. RESULT(S): Live birth followed 14 of 127 (11%) superovulation and IUI cycles and 4 of 184 (2%) no-treatment cycles. The odds ratio was 5.6 (95% confidence interval 1.8 to 17.4) in favor of superovulation and IUI. CONCLUSION(S): Treatment with superovulation and IUI was associated with superior outcome both by crude live-birth rates and proportional hazard analysis.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Infertility, Female Insemination, Artificial Insemination, Artificial Pregnancy Outcome Pregnancy Outcome Superovulation Superovulation Adult Adult Analysis of Variance Analysis of Variance Endometriosis Endometriosis Endometriosis Female Female Follicle Stimulating Hormone Follicle Stimulating Hormone Follicle Stimulating Hormone

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (16)

Cited by (50)

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