A randomized and longitudinal study of human menopausal gonadotropin with intrauterine insemination in the treatment of infertility.
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Human menopausal gonadotropin with intrauterine insemination demonstrated higher cycle fecundity and pregnancy rates compared to intrauterine insemination alone for infertility due to endometriosis, male factors, or unexplained causes.
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Abstract
OBJECTIVE: To study in a randomized and longitudinal manner the efficacy of human menopausal gonadotropin (hMG) superovulation combined with intrauterine insemination (IUI) versus IUI alone in the treatment of various causes of infertility in the presence of normal ovulation. METHODS: An initially randomized and subsequently longitudinal study of infertile couples was performed at a university-based clinical research center. One hundred nineteen couples with longstanding infertility (average duration 3.7 years) associated with male factor infertility, unexplained infertility, and/or endometriosis were enrolled. All patients were randomized in the initial cycle to treatment with either hMG/IUI or urine LH-timed IUI alone. They were then followed longitudinally as they alternated subsequent cycles between the two modalities. Outcome indices measured were cycle fecundity, pregnancy outcome, and cumulative pregnancy rates evaluated by life-table analysis. RESULTS: Human menopausal gonadotropin/IUI therapy was consistently more effective than IUI alone in the treatment of endometriosis, male factor infertility, and unexplained infertility, with cycle fecundities ranging from 7.1-19.0% versus 0-6.7%, respectively, during the first seven cycles. CONCLUSION: Human menopausal gonadotropin/IUI is a more effective therapy for enhancing fertility than is IUI alone for the treatment of endometriosis, male factor infertility, and unexplained infertility.
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Cited by (41)
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- Endometriosis Associated Infertility: A Critical Review and Analysis on Etiopathogenesis and Therapeutic Approaches 2020
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- When more is not better: 10 ‘don’ts’ in endometriosis management. An ETIC* position statement 2019
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- Endometriose und Kinderwunsch – was nun? 2017
- Non-ART pregnancy predictive factors in infertile patients with peritoneal superficial endometriosis 2017
- Management of Infertility in Women with Endometriosis 2017
- Pregnancy Rates after Intrauterine Insemination in Moderate to Severe Endometriosis: A Systematic Review and Meta-analysis of Observational Studies 2017
- Aromatase Inhibitors for Endometriosis-Associated Infertility; Do We Have Sufficient Evidence? 2016
- Open-label, Prospective, Investigator Initiated Study to Assess the Clinical Role of Oral Natural or Synthetic Progesterone During Stimulated IUI Cycles for Unexplained Infertility 2016
- Endometriosis‐associated infertility: aspects of pathophysiological mechanisms and treatment options 2016
- Руководство европейского общества репродукции человека и эмбриологии (ESHRE): менеджмент женщин с эндометриозом 2014
- Potential role of aromatase inhibitors in the treatment of endometriosis 2014
- Predictive factors for pregnancy during the first four intrauterine insemination cycles using gonadotropin 2013
- Place des techniques d’assistance médicale à la procréation 2010
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- Tratamiento de la endometriosis I y II. Revisión de la literatura 2008
- TRATAMIENTO DE LA ENDOMETRIOSIS I Y II: REVISIÓN DE LA LITERATURA A review of the literature concerning treating endometriosis I and II 2008
- No difference in cycle pregnancy rate and in cumulative live-birth rate between women with surgically treated minimal to mild endometriosis and women with unexplained infertility after controlled ovarian hyperstimulation and intrauterine insemination 2006
- COMPARISON OF TIMING OF IUI IN OVARIAN STIMULATED CYCLES 2006
- Impact of leuprolide acetate on luteal phase function in women undergoing controlled ovarian hyperstimulation and intrauterine insemination 2006
- A COMPARISON OF CLOMIPHENE CITRATE AND SEQUENTIAL CLOMIPHENE CITRATE PLUS HUMAN MENOPAUSAL GONADOTROPIN FOR USE IN CONJUNCTION WITH INTRAUTERINE INSEMINATION 2005
- Prediction of an ongoing pregnancy after intrauterine insemination 2004
- Stimulated intra-uterine insemination is not a natural choice for the treatment of unexplained subfertility: Should the guidelines be changed? 2003
- In Vitro Fertilization or Superovulation? Evidence, Flaws and Advice 2003
- Fertility Treatment in the Forty and Older Woman 2001
- Superovulation and Intrauterine Insemination in Cases of Treated Mild Pelvic Disease 2001
- Bénéfices et risques de la stimulation ovarienneen vue d’inséminations intra-utérines 2000
- Intrauterine insemination (IUI) treatment in subfertility 1999
- Chapter 8 Endometriosis-associated Infertility and Ovulation Induction 1999
- Intrauterine insemination treatment in subfertility: an analysis of factors affecting outcome 1999
- Efficacy of treatment for unexplained infertility 1998
- A comparison of clomiphene citrate and human menopausal gonadotropin for use in conjunction with intrauterine insemination 1997
- Randomized controlled trial of superovulation and insemination for infertility associated with minimal or mild endometriosis 1997
- Endometriosis-associated infertility 1997
- Minimal stimulation achieves pregnancy rates comparable to human menopausal gonadotropins in the treatment of infertility 1996
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