A comparison of clomiphene citrate and human menopausal gonadotropin for use in conjunction with intrauterine insemination

Paul D. Manganiello; Judy E. Stern; Thérèse A. Stukel; Harte C. Crow; Truls Brinck‐Johnsen; Julie E. Weiss

doi:10.1016/s0015-0282(97)00260-4

A comparison of clomiphene citrate and human menopausal gonadotropin for use in conjunction with intrauterine insemination

Paul D. Manganiello, Judy E. Stern, Thérèse A. Stukel, Harte C. Crow, Truls Brinck‐Johnsen, Julie E. Weiss

In: Fertility and Sterility · 1997 · vol. 68(3) , pp. 405–412 · doi:10.1016/s0015-0282(97)00260-4 · PMID:9314905 · W2071251566

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This study compared clomiphene citrate and human menopausal gonadotropin when used with intrauterine insemination, assessing their effectiveness in fertility treatment.

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Abstract

ObjectiveTo compare the outcome of superovulation using clomiphene citrate (CC) versus hMG in conjunction with IUI.DesignSequentially assigned, observational study. Couples initially were assigned to receive either CC or hMG for three cycles.SettingThe Clinical Outpatient Department of the Dartmouth-Hitchcock Medical Center.Patient(s)Eighty-three infertile couples.Intervention(s)IUI with hMG use.Main outcome measure(s)Conception rate, term pregnancy rate (PR), and pregnancy complications, such as spontaneous miscarriage and multiple gestation.Result(s)Of 83 couples who underwent at least one treatment cycle, 29 (35%) conceived during the study period. The relative rate of conception for hMG versus CC was 2.08 (95% confidence interval [CI], 0.93 to 4.68). The relative term PR was 2.10 (95% CI, 0.77 to 5.73) for hMG versus CC. There was no difference in the miscarriage rate for hMG versus CC.Conclusion(s)Both the conception rate and the term PR were higher using hMG, compared with CC, in combination with IUI, and showed a trend toward statistical significance.

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[1] A prospective, randomized trial comparing two different intrauterine insemination regimens in controlled ovarian hyperstimulation cycles via openalex

[2] A prospective randomized trial of artificial insemination versus intercourse in cycles stimulated with human menopausal gonadotropin or clomiphene citrate via openalex

[3] A randomized and longitudinal study of human menopausal gonadotropin with intrauterine insemination in the treatment of infertility. via openalex

[4] A randomized, controlled trial of clomiphene citrate and intrauterine insemination in couples with unexplained infertility or surgically corrected endometriosis via openalex

[5] Menotropins alone are superior to a clomiphene citrate and menotropin combination for superovulation induction among clomiphene citrate failures via openalex

[6] Relationship of endometrial thickness and pattern to fecundity in ovulation induction cycles: effect of clomiphene citrate alone and with human menopausal gonadotropin via openalex

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