A comparison of clomiphene citrate and human menopausal gonadotropin for use in conjunction with intrauterine insemination

Paul D. Manganiello; P D Manganiello; J E Stern; Judy E. Stern; Thérèse A. Stukel; T A Stukel; Harte C. Crow; H Crow; T Brinck-Johnsen; Truls Brinck‐Johnsen; Julie E. Weiss; J E Weiss

doi:10.1016/s0015-0282(97)00260-4

A comparison of clomiphene citrate and human menopausal gonadotropin for use in conjunction with intrauterine insemination

Paul D. Manganiello, P D Manganiello, J E Stern, Judy E. Stern, Thérèse A. Stukel, T A Stukel, Harte C. Crow, H Crow, T Brinck-Johnsen, Truls Brinck‐Johnsen, Julie E. Weiss, J E Weiss

Fertility and sterility · 1997 · vol. 68(3) , pp. 405–412 · doi:10.1016/s0015-0282(97)00260-4 · PMID:9314905 · W2071251566

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This study compared clomiphene citrate and human menopausal gonadotropin when used with intrauterine insemination, assessing their effectiveness in fertility treatment.

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Abstract

OBJECTIVE: To compare the outcome of superovulation using clomiphene citrate (CC) versus hMG in conjunction with IUI. DESIGN: Sequentially assigned, observational study. Couples initially were assigned to receive either CC or hMG for three cycles. SETTING: The Clinical Outpatient Department of the Dartmouth-Hitchcock Medical Center. PATIENT(S): Eighty-three infertile couples. INTERVENTION(S): IUI with hMG use. MAIN OUTCOME MEASURE(S): Conception rate, term pregnancy rate (PR), and pregnancy complications, such as spontaneous miscarriage and multiple gestation. RESULT(S): Of 83 couples who underwent at least one treatment cycle, 29 (35%) conceived during the study period. The relative rate of conception for hMG versus CC was 2.08 (95% confidence interval [CI], 0.93 to 4.68). The relative term PR was 2.10 (95% CI, 0.77 to 5.73) for hMG versus CC. There was no difference in the miscarriage rate for hMG versus CC. CONCLUSION(S): Both the conception rate and the term PR were higher using hMG, compared with CC, in combination with IUI, and showed a trend toward statistical significance.

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MeSH descriptors

Clomiphene Fertility Agents, Female Insemination, Artificial, Homologous Menotropins Adult Clomiphene Estradiol Estradiol Female Fertility Agents, Female Humans Male Menotropins Ovulation Ovulation Pregnancy

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[1] A prospective, randomized trial comparing two different intrauterine insemination regimens in controlled ovarian hyperstimulation cycles via openalex

[2] A prospective randomized trial of artificial insemination versus intercourse in cycles stimulated with human menopausal gonadotropin or clomiphene citrate via openalex

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