Superovulation and Intrauterine Insemination in Cases of Treated Mild Pelvic Disease

Purpose: Our purpose was to examine the effect of treated mild pelvic disease on the outcome of superovulation with intrauterine insemination (SO/IUI).

Three hundred cycles of SO/IUI were retrospectively reviewed for 118 women with laparoscopically treated minimal/mild endometriosis and 67 cycles for 28 women with minimal/mild distal tubal disease/adnexal adhesions and compared with 265 cycles in 111 couples with idiopathic infertility.

The monthly fecundity rate (MFR) of 6.8% and live birth rate (LBR) of 6% in the endometriosis group were significantly lower (P = 0.002) than those in the idiopathic infertility group (MFR = 13.5%, LBR = 12.1%). The 10.9% MFR and 7.5% LBR in the minimal/mild tubal/adnexal disease were not significantly different from those in the other two groups.

MFR and LBR were higher after SO/IUI in idiopathic infertility compared to those for treated mild/minimal endometriosis or mild/minimal tubal/adnexal adhesions. However, SO/IUI still remains a reasonable option for both these groups prior to IVF-ET. Similar content being viewed by others

Collins JA, Burrows EA, Willan AR: The prognosis for live birth among untreated infertile couples. Fertil Steril 1995;64:22-28 Tummon I, Asher L, Martin J, Tulandi T: Randomized controlled trial of superovulation and insemination for infertility associated with minimal or mild endometriosis. Fertil Steril 1997;68:8-12 Fedele L, Bianchi S, Marchini M, Villa L, Brioschi D, Parazzini F: Superovulation with human menopausal gonadotrophins in the treatment of infertility associated with minimal or mild endometriosis: A controlled randomized study. Fertil Steril 1992;58:28-31 Marcoux S, Maheux R, Sylvie Berube, Canadian Collaborative Group on Endometriosis: Laparoscopic surgery in infertile women with minimal or mild endometriosis. N Engl J Med 1997;337:217-222 Hendin B, Falcone T, Hallak J, Nelson D, Vemullapalli S, Goldberg J, Thomas A, Agarwal A: The effect of patient and semen characteristics on live birth rates following intrauterine insemination: A retrospective study. J Assist Reprod Genet 2000;17:245-252 American Fertility Society: Revised classification of endometriosis. Fertil Steril 1985;43:351-352 American Fertility Society: The American Fertility Society classification of adnexal pregnancies, to tubal ligation, adhesions, distal tubal occlusion, tubal occlusion secondary tubal Mullerian anomalies and intrauterine adhesions. Fertil Steril 1988;49:944-955 Nulsen JC, Walsh S, Dumez S, Metzer D: A Randomized and Longitudinal study of human menopausal gonadotrophin with intrauterine insemination in the treatment of infertility. Obstet Gynecol 1993;82:780-786 Dodson WC, Haney AF: Controlled ovarian hyperstimulation and intrauterine insemination for treatment of infertility. Fertil Steril 1991;55:457-465 Guzick DS, Carson SA, Coutifaris C, Overstreet JW, Factor-Litvak P, Steinkampf MP, Joseph A, Mastroianni LJ, Buster JE, Nakajima ST, Vogel DL, Canfield RE: Efficacy of superovulation and intrauterine insemination in the treatment of infertility. N Engl J Med 1999;340:177-183 Agarwell SK, Buyalos RP: Clomiphene citrate with intrauterine insemination: Is it effective therapy in women above the age of 35 years? Fertil Steril 1996;65:759-763 Corsan G, Trias A, Trout S, Kemmann E: Ovulation induction combined with intrauterine insemination in women of 40 years of age and older: Is it worthwhile? Hum Reprod 1996; 11:1109-1112 Lenton EA, Weston GA, Cooke ID: Long-term follow-up of the apparently normal couple with a complaint of infertility. Fertil Steril 1977;28:913-919 Matson PL, Yovich JL: The treatment of infertility associated with endometriosis by in vitro fertilization. Fertil Steril 1986;46:432-434 Goverde AJ, McDonnell J, Vermeiden JPW, Schats R, Rutten FFH, Schoemaker J: Intrauterine insemination or in-vitro fertilisation in idiopathic subfertility and male subfertility: A randomised trial and cost-effectiveness analysis. Lancet 2000;355:13-18 Peterson CM, Hatasaka HH, Jones KP, Poulson AM, Carrell DT, Urry RL: Ovulation induction with gonadotrophins and intrauterine insemination compared with in vitro fertilization and no therapy: A prospective, nonrandomized, cohort study and metaanalysis. Fertil Steril 1994;62:535-544 Author information Authors and Affiliations Rights and permissions About this article Cite this article Singh, M., Goldberg, J., Falcone, T. et al. Superovulation and Intrauterine Insemination in Cases of Treated Mild Pelvic Disease. J Assist Reprod Genet 18, 26–29 (2001). https://doi.org/10.1023/A:1026446612485 Issue date: DOI: https://doi.org/10.1023/A:1026446612485